25932-48-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Quinolinamine, N-methyl-N-phenylis used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Quinolinamine, N-methyl-N-phenylserves as an intermediate in the production of agrochemicals. Its role in this industry is crucial for the development of effective pesticides and other agricultural products that protect crops and enhance agricultural yields.
Used in Dye and Pigment Production:
2-Quinolinamine, N-methyl-N-phenylis utilized in the manufacturing of dyes and pigments, where its chemical properties contribute to the creation of vibrant and stable colorants for various applications, including textiles, plastics, and printing inks.
Used in Anticancer Research:
2-Quinolinamine, N-methyl-N-phenylis used as a subject of study in anticancer research for its potential to inhibit the growth of certain cancer cells. While preliminary results are promising, ongoing research is essential to understand its full potential and effects in the field of oncology.

Upstream product

• 612-62-4 2-Chloroquinoline 
• 100-61-8 N-methylaniline 
• 1613-37-2 Quinoline N-oxide 
• 93-61-8 N-methyl-N-phenylformamide 
• 1436-43-7 quinoline-2-carbonitrile 
• 101444-29-5 N-methyl-N-phenyl-2-quinolinecarboxamide 
• 6931-16-4 2-methoxy-quinoline 

Relevant academic research and scientific papers

Heteroarylation method of amine

The invention discloses a heteroarylation method of amine, and the method comprises the following steps of: mixing an amine compound, heteroaromatic hydrocarbon, a photocatalyst and an organic solventto obtain a solution A; and in an inert gas atmosphere, irradiating the solution A with visible light, and carrying out reaction to obtain a heteroarylated product of amine. According to the method,under mild conditions, free radical coupling of amine compounds and heteroaromatic compounds is efficiently achieved through visible light irradiation, and various heteroarylamines are synthesized. The method has good functional group compatibility and high regioselectivity, can be further applied to later modification of bioactive molecules, and shows a good industrial application prospect.

Design of Benzimidazolyl Phosphines Bearing AlterableP,OorP,N-Coordination: Synthesis, Characterization, and Insights into Their Reactivity

A new series of hemilabile benzimidazolyl phosphines is reported. Entities in this ligand family can be easily assembled and prepared on a large scale via a simple one-pot procedure. X-ray crystallographic analyses show that the Pd metal center can coordinate in different fashions, where it relies on the size of the ?PR2group. With the same ligand scaffold, the ligand having a ?PCy2moiety displays better efficiency in expediting aromatic C-C bond-coupling reactions, while the ligand associated with a ?P-t-Bu2group, in contrast, promotes C-N bond-forming reactions.

Metal-free, redox-neutral, site-selective access to heteroarylamine via direct radical?radical cross-coupling powered by visible light photocatalysis

Transition-metal-catalyzed C?N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chemicals. Reported herein is an alternative access to heteroarylamine via radical?radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C?N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C?N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings.

Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes

We report that the organic superbase t-Bu-P4 efficiently catalyzes the amination of methoxy(hetero)arenes with amine nucleophiles such as aniline, indoline, and aminopyridine derivatives. This catalytic reaction is effective for the transformation of elec

Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.

The First Rapid Palladium-Catalyzed Aminations of (Azahetero)aryl Chlorides under Temperature-Controlled Microwave Heating

Fast palladium-catalyzed animations of activated and unactivated azaheteroaryl chlorides as well as unactivated aryl chlorides have been achieved using temperature-controlled microwave heating. Good yields (75-91%) were obtained in a reaction time of only 10 minutes.