25941-06-4Relevant academic research and scientific papers
Synthesis and Biological Evaluation of N2-Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors
Cortese, Daniela,Chegaev, Konstantin,Guglielmo, Stefano,Wang, Lan Z.,Golding, Bernard T.,Cano, Céline,Fruttero, Roberta
, p. 1705 - 1708 (2016)
The potent and selective cyclin-dependent kinase 2 (CDK2) inhibitor NU6027 (6-cyclohexylmethoxy-5-nitroso-2,4-diaminopyrimidine) was used as the lead for the synthesis of a series of analogues in order to provide further insight into the structure–activit
Anaerobic nitroxide-catalyzed oxidation of alcohols using the NO +/NO· redox pair
Holan, Martin,Jahn, Ullrich
supporting information, p. 58 - 61 (2014/01/23)
A new method for alcohol oxidation using TEMPO or AZADO in conjunction with BF3·OEt2 or LiBF4 as precatalysts and tert-butyl nitrite as a stoichiometric oxidant has been developed. The system is based on a NO+/NO· pair for nitroxide reoxidation under anaerobic conditions. This allows the simple, high-yielding conversion of various achiral and chiral alcohols to carbonyl compounds without epimerization and no formation of nonvolatile byproducts.
