259541-93-0

Upstream product

• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 1187334-96-8 C₂₃H₂₄N₂O₅ 
• 1241667-99-1 4-[2-(4-methoxyphenyl)pyrimidin-4-yl]benzoic acid ethyl ester 
• 1241668-02-9 4-[2-(4-trifluoromethylphenyl)pyrimidin-4-yl]benzoic acid ethyl ester 

Relevant academic research and scientific papers

Cobalt-catalyzed C-SMe bond activation of heteroaromatic thioethers

Cobalt-catalyzed activation of methylthio-substituted N-heterocycles facilitates either cross-coupling reactions with aryl- or benzylzinc compounds or synthesis of the corresponding zinc compounds.

Cobalt-catalyzed cross-coupling between in situ prepared arylzinc halides and 2-chloropyrimidine or 2-chloropyrazine

A cobalt-catalyzed cross-coupling of aryl halides with 2-chloropyrimidines or 2-chloropyrazines is reported in satisfactory to high yields. The key step of this procedure is the formation of aromatic organozinc reagents and their coupling with 2-chlorodia

Electrochemical cross-coupling between functionalized aryl halides and 2-chloropyrimidine or 2-chloropyrazine catalyzed by nickel 2,2'-bipyridine complex

2-Arylpyrimidines and 2-arylpyrazines have been obtained in good to high yields from 2-chloropyrimidine and 2-chloropyrazine and various functionalized aryl halides by electroreduction using an iron rod as the anode and a catalytic amount of nickel-bipyridine complex in a mixture of DMF and pyridine as solvent.