259546-80-0Relevant academic research and scientific papers
Intramolecular aza-anti-Michael addition of an amide anion to enones: A regiospecific approach to tetramic acid derivatives
Bi, Xihe,Zhang, Jingping,Liu, Qun,Tan, Jing,Li, Bing
, p. 2301 - 2306 (2008/09/19)
A novel intramolecular aza-anti-Michael addition was disclosed in the one-pot reactions between 3-oxobutanamides and aryl (heteroaryl) aldehydes under basic conditions, in which amide anions regiospecifically attacked the ct-carbon of an enone fragment, p
A facile and efficient synthesis of 3,5-disubstituted tetronic acids in aqueous media involving acid-catalyzed intramolecular oxa-pyridylethylation
Bi, Xihe,Liu, Qun,Sun, Shaoguang,Liu, Jun,Pan, Wei,Zhao, Lei,Dong, Dewen
, p. 49 - 54 (2007/10/03)
A facile and efficient one-pot synthesis of 3-[bis(alkylthio/alkylamino) methylene]-5-(pyridyl/quinoylmethyl) furan-2,4(3H,5H)-diones 3 and 10, based on a sequential aldol condensation and lactonization reaction between α-oxo ketene-S,S-acetals 1 and pyridine/qinoline-carboxaldehydes 2 in aqueous media, has been developed. A mechanism involving an acid-catalyzed intramolecular oxa-pyridylethylation reaction is proposed for the formation of the lactone ring.
