259662-70-9Relevant academic research and scientific papers
Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative
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, (2008/06/13)
The present invention provides a method of treatment of a disease associated with neurodegeneration by administering a therapeutically effective amount of a compound of the general formula whereinAr1 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonamide;Ar2 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by lower alkyl or halogen;X is C, CH, C(OH) or N;Y is —CH2?, CH or O;Z —CH2—, —CH(CH3)— or —C(CH3)2—;R1 is hydrogen, lower alkyl or acetyl;A is C=O or —(CHR2)n—, wherein R2 is hydrogen, lower alkyl or hydroxy-lower alkyl;B is —(CH2)n—, O, —CH(OH)(CH2)n—, —CH(CH2OH)(CH2)n—, —(CH2)n CH(OH)— or —CH(CH2OH)—;- - - may be a bond; andn is 0-4,or pharmaceutically acceptable acid addition salts thereof.
