259667-67-9

Basic information

• Product Name: (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid
• Synonyms: (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid
• CAS NO: 259667-67-9
• Molecular Weight: 375.043
• Mol File: 259667-67-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid(259667-67-9)
• EPA Substance Registry System: (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid(259667-67-9)

Safety Data

• Hazardous Substances Data: 259667-67-9(Hazardous Substances Data)

Upstream product

• 259667-65-7 5-iodo-2-methyl-1-nitro-3-(trifluoromethyl)benzene 
• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 
• 685136-16-7 3-(4-iodo-2-nitro-6-trifluoromethyl-phenyl)-2-oxo-propionic acid 
• 259667-66-8 methyl (4-iodo-6-nitro-2-trifluoromethylphenyl)pyruvate 

Downstream Products

• 259667-68-0 methyl (4-iodo-6-nitro-2-trifluoromethylphenyl)acetate 

Relevant articles and documents

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

A concise and regioselective synthesis of 6-iodo-4-trifluoromethylisatin, an intermediate in the synthesis of the novel, non-peptidyl growth hormone secretagogue SM-130686

The synthesis of 6-iodo-4-trifluoromethylisatin, an intermediate in the synthesis of the growth hormone secretagogue SM-130686, is disclosed. The synthesis is achieved in seven steps, with an overall yield of 32%, and requires a single recrystallisation as the only purification step. 2-Methyl-3-nitrobenzotrifluoride was converted to (4-iodo-6-nitro-2-trifluoromethylphenyl)acetic acid via iodination, condensation with dimethyloxalate and oxidative decarboxylation. Subsequent esterification followed by reductive cyclisation gave 6-iodo-4-trifluoromethyloxindole. Oxindole 3,3-dibromination followed by hydrolysis gave 6-iodo-4-trifluoromethylisatin.