25967-29-7

Basic information

• Product Name: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-
• Synonyms: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-;Flutoprazepam;7-Chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1，3-dihydro-2H-1，4-benzodiazepin-2-one;ID-1937;KB-509;Restar;Restas;KB-509P
• CAS NO: 25967-29-7
• Molecular Formula: C₁₉H₁₆ClFN₂O
• Molecular Weight: 342.79
• Mol File: 25967-29-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 118-122°
• Boiling Point: 539.3 °C at 760 mmHg
• Flash Point: 279.9 °C
• Appearance: /
• Density: 1.2683 (estimate)
• Vapor Pressure: 1.07E-11mmHg at 25°C
• Refractive Index: 1.661
• PKA: 1.93±0.35(Predicted)
• CAS DataBase Reference: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(25967-29-7)
• EPA Substance Registry System: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(25967-29-7)

Safety Data

• Hazardous Substances Data: 25967-29-7(Hazardous Substances Data)

Usage

Description

Flutoprazepam is a benzodiazepine anti-anxiety agent, somewhat longer acting and more potent than diazepam.

Originator

Sumitomo (Japan)

Brand name

RESTAS

InChI:InChI=1/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2

Relevant articles and documents

Process for the preparation of 1,4-benzodiazepine derivatives

A 1,4-benzodiazepine derivative, or a pharmaceutically acceptable acid salt thereof, of the formula, SPC1 Wherein R1 is hydrogen, halogen, nitro or trifluoromethyl; R2 and R3 are independently hydrogen, halogen, lower alkyl or trifluoromethyl; R4 is lower alkyl, alkenyl, trihaloalkyl, alkoxyalkyl, alkenyloxyalkyl, alkoxyalkoxyalkyl, alkanoyloxyalkyl, cycloalkylalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl or a group of the formula EQU1 in which R6 and R7 are independently lower alkyl, and n is an integer of 1 to 4; and R5 is hydrogen or lower alkyl, is obtained by reacting a benzophenone derivative of the formula, SPC2 Wherein R1, R2, R3 and R4 are as defined above, with a 2-isocyanatoacetyl chloride derivative of the formula EQU2 wherein R5 is as defined above.