259676-58-9Relevant academic research and scientific papers
BINOL-Ti-Catalyzed carbonyl-ene cyclization by tuning the 6-Br-ligand for the synthesis of 2-methyl-19-nor-22-oxa vitamin D analogue with significant differentiation activity
Mikami, Koichi,Koizumi, Yurika,Osawa, Ayako,Terada, Masahiro,Takayama, Hiroaki,Nakagawa, Kimie,Okano, Toshio
, p. 1899 - 1902 (2007/10/03)
Transition state control in BINOL-Ti-catalyzed asymmetric carbonyl-ene cyclization by tuning the 6-Br-BINOL ligand completes the synthesis of the A ring of the 2-methyl-19-nor-22-oxa D3 analogue (2), which shows the significant activity in differentiation of HL-60 cell.
