259752-90-4Relevant academic research and scientific papers
Enantioselective total synthesis of a potent antitumor antibiotic, fredericamycin A
Kita,Higuchi,Yoshida,Iio,Kitagaki,Ueda,Akai,Fujioka
, p. 3214 - 3222 (2007/10/03)
The asymmetric total synthesis of both enantiomers of the potent antitumor antibiotic fredericamycin A (1) is detailed based on the protocol for the construction of its peri-hydroxy polyaromatic skeleton bearing the chirality at the spiro carbon via a str
Asymmetric total synthesis of fredericamycin A
Kita, Yasuyuki,Higuchi, Kazuhiro,Yoshida, Yutaka,Iio, Kiyosei,Kitagaki, Shinji,Akai, Shuji,Fujioka, Hiromichi
, p. 683 - 686 (2007/10/03)
Seventeen years after the isolation of the promising antitumor antibiotic fredericamycin A, the first asymmetric total synthesis of this compound has been accomplished and thereby its absolute configuration established. The key feature is the regiocontrol
