259794-53-1

Basic information

• Product Name: tert-Butyl 3-amino-2,2-dimethylpropanoate
• Synonyms: tert-Butyl 3-amino-2,2-dimethylpropanoate
• CAS NO: 259794-53-1
• Molecular Formula: C₉H₁₉NO₂
• Molecular Weight: 173.25266
• Mol File: 259794-53-1.mol

Chemical Properties

• Boiling Point: 221.7±23.0 °C(Predicted)
• Appearance: /
• Density: 0.939±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.75±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 3-amino-2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3-amino-2,2-dimethylpropanoate(259794-53-1)
• EPA Substance Registry System: tert-Butyl 3-amino-2,2-dimethylpropanoate(259794-53-1)

Safety Data

• Hazardous Substances Data: 259794-53-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-Butyl 3-amino-2,2-dimethylpropanoate is used as an active pharmaceutical ingredient for the treatment of Hepatitis B Virus (HBV) infection or HBV-induced diseases. Its unique structure allows it to target and combat the virus effectively, providing a potential therapeutic option for patients suffering from HBV-related conditions.

Upstream product

• 75235-66-4 cyano-dimethylacetic acid tert-butyl ester 
• 259794-51-9 methyl 2,2-dimethyl-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoate 
• 80253-36-7 3-(benzyloxycarbonylamino)-2,2-dimethylpropanoic acid 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 19036-43-2 aminopivalic acid 
• 259794-52-0 tert-butyl 3-{[(benzyloxy)carbonyl]amino}-2,2-dimethylpropanoate 

Downstream Products

• 1455091-78-7 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455087-34-9 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455092-29-1 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455087-53-2 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455094-67-3 3-[(1-cyano-7-cyclohexyloxy-4-hydroxy-isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid tert-butyl ester 
• 1455090-36-4 3-[(1-cyano-7-cyclohexanesulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455090-28-4 3-[(1-cyano-7-cyclohexyloxy-4-hydroxy-isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455087-29-2 3-{[1-cyano-4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455091-57-2 3-{[1-cyano-4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455089-06-1 3-{[1-cyano-7-(4-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455089-03-8 3-{[7-(2-chloro-4-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455093-66-9 3-{[7-(2-chloro-4-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455087-31-6 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester 
• 1455091-72-1 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester 

Relevant articles and documents

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS

The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.

Synthesis of 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and evaluation of their affinity for MHC class-II proteins

1,2,5-Thiadiazolidin-3-one 1,1-dioxide derivatives (±)-1a-d and (±)-2 were designed by molecular modeling as MHC (major histocompatibility complex) class-II inhibitors. They were prepared from the unsymmetrically N,N'- disubstituted acyclic sulfamides (±)