259799-90-1Relevant articles and documents
An efficient method to chiral β-hydroxy acids: Synthesis of lipid-A side chain
Nandanan,Phukan, Prodeep,Sudalai
, p. 893 - 896 (2007/10/03)
The synthesis of optically active β-hydroxy acids 5a-c is achieved in four steps from their corresponding terminal olefins 1a-c by employing Sharpless asymmetric dihydroxylation. The regioselective ring opening of chiral cyclic sulfites 3a-c with cyanide ion, constitutes the key reaction, thus producing the hydroxy nitriles 4a-c.