259822-63-4Relevant articles and documents
Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists
Fotouhi, Nader,Joshi, Pramod,Tilley, Jefferson W.,Rowan, Karen,Schwinge, Virginia,Wolitzky, Barry
, p. 1167 - 1169 (2007/10/03)
Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on ring size and the position of the sulfur atom. (C) 2000 Elsevier Science Ltd. All rights reserved.
The first asymmetric syntheses of L-homocysteine and L-homocystine
Adamczyk, Maciej,Fishpaugh, Jeffrey R.,Thiruvazhi, Mohan
, p. 4151 - 4156 (2007/10/03)
Asymmetric syntheses of L-homocysteine 1 and L-homocystine 2 are described. Alkylation of the carbanion derived from Schollkopf reagent 3 and ensuing hydrolyses gave S-triphenylmethyl-L-homocysteine 6. Removal of the triphenylmethyl group gave L-homocysteine 1 and subsequent oxidation provided L-homocystine 2.