259822-63-4

Upstream product

• 3695-77-0 triphenylmethanethiol 
• 157522-54-8 2-bromoethyl triphenylmethyl sulfide 
• 259822-62-3 (2R,5S)-2-isopropyl-3,6-dimethoxy-5-[2-(tritylsulfanyl)ethyl]-2,5-dihydropyrazine 

Downstream Products

• 69955-57-3 (2S)-2-amino-4-(tritylsulfanyl)butanoic acid 
• 289913-38-8 (S)-2-{[1-(2-Azido-ethyl)-cyclopentanecarbonyl]-amino}-4-tritylsulfanyl-butyric acid methyl ester 
• 289913-48-0 (8S,14S)-14-Benzyloxycarbonylamino-6,15-dioxo-11-thia-7,16-diaza-spiro[4.13]octadecane-8-carboxylic acid methyl ester 
• 289913-44-6 (S)-2-({1-[2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-butyrylamino)-ethyl]-cyclopentanecarbonyl}-amino)-4-tritylsulfanyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists

Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on ring size and the position of the sulfur atom. (C) 2000 Elsevier Science Ltd. All rights reserved.

The first asymmetric syntheses of L-homocysteine and L-homocystine

Asymmetric syntheses of L-homocysteine 1 and L-homocystine 2 are described. Alkylation of the carbanion derived from Schollkopf reagent 3 and ensuing hydrolyses gave S-triphenylmethyl-L-homocysteine 6. Removal of the triphenylmethyl group gave L-homocysteine 1 and subsequent oxidation provided L-homocystine 2.