259826-43-2

Usage

Uses

Used in Organic Synthesis:
(1R, 2R, 5S)-NEOMENTHYL AZIDE is used as a nitrogen source for the preparation of various nitrogen-containing compounds, contributing to the development of new organic molecules with potential applications in various fields.
Used in Click Chemistry Reactions:
(1R, 2R, 5S)-NEOMENTHYL AZIDE is used as a versatile reagent in click chemistry reactions, which are a set of powerful and highly efficient coupling processes that are widely used in the synthesis of complex molecules and the formation of molecular assemblies.
Used in Pharmaceutical Compounds Synthesis:
(1R, 2R, 5S)-NEOMENTHYL AZIDE is used as a key intermediate in the synthesis of bioactive molecules and pharmaceutical compounds, facilitating the development of new drugs and therapeutic agents.
Used in the Synthesis of Bioactive Molecules:
(1R, 2R, 5S)-NEOMENTHYL AZIDE is used as a building block in the synthesis of bioactive molecules, which have potential applications in medicine, agriculture, and other industries, due to their ability to interact with biological targets and exhibit specific biological activities.

Upstream product

• 959925-33-8 (1S,2R,5S)-2-i-propyl-5-methylcyclohexyl 4-methylbenzenesulfonate 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 2216-51-5 (-)-menthol 
• 2230-82-2 menthyl tosylate 

Downstream Products

• 51743-63-6 (+)-neomenthylamine 
• 1446348-66-8 C₁₁H₁₉N 
• 34048-58-3 N-((1S)-neomenthyl)-formamide 
• 5033-85-2 (1R,2R,4S) 1-isopropyl-4-methyl-2-nitrocyclohexane 

Relevant academic research and scientific papers

Oxidation of azides by the HOF·CH3CN: A novel synthesis of nitro compounds

The HOF·CH3CN complex, readily prepared by passing F 2 through aqueous acetonitrile, is an exceptionally efficient oxygen transfer agent. It is unique in its capacity to oxidize various azides into the corresponding nitro derivatives. This method requires short reactions times and room temperature or below, and the desired nitro compounds were usually isolated in very good yields. The respective nitroso derivatives are believed to be the intermediates in this reaction. Functional groups such as aromatic rings, ketones, nitriles, halides, alcohols, and esters are tolerated. Sulfides react with HOF·CH3CN usually at the same rate as azides. Amines and olefins, however, react faster, so they have to be protected first. Nitro derivatives with various oxygen isotopes can be made using the labeled H 18OF·CH3CN. In the case of chiral azides the stereochemistry around the nitrogen-bonded carbons is retained.

Nicotinoyl azide (NCA)-mediated Mitsunobu reaction: An expedient one-pot transformation of alcohols into azides

A practical and simple method that allows preparation of azides from alcohols is described. The process involves oxyphosphonium-type activation and it is based upon the use of nicotinoyl azide (NCA), a cheap and easily accessible azide ion source.

A simple and convenient synthesis of alkyl azides under mild conditions

Various primary and secondary alkyl azides have been synthesized in high yields by the fluoride anion induced S(N)2 substitution reactions of the corresponding alkyl halides, phosphates, or tosylates and trimethylsilyl azide.

Zinc Azide Mediated Mitsunobu Substitution. An Expedient Method for the One-Pot Azidation of Alcohols

In the presence of the diisopropyl azodicarboxylate/triphenylphosphine couple, alcohols react with zinc azide/bis-pyridine complex to give various azides via a Mitsunobu-type substitution.