25999-04-6

Basic information

• Product Name: 4-Morpholinesulfonamide(8CI,9CI)
• Synonyms: 4-Morpholinesulfonamide(8CI,9CI);4-Morpholinesulfonamide
• CAS NO: 25999-04-6
• Molecular Formula: C₄H₁₀N₂O₃S
• Molecular Weight: 166.2
• Product Categories: SULFONAMIDE
• Mol File: 25999-04-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 331.4°Cat760mmHg
• Flash Point: 154.3°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 0.000156mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.30±0.20(Predicted)
• CAS DataBase Reference: 4-Morpholinesulfonamide(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinesulfonamide(8CI,9CI)(25999-04-6)
• EPA Substance Registry System: 4-Morpholinesulfonamide(8CI,9CI)(25999-04-6)

Safety Data

• Hazardous Substances Data: 25999-04-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H10N2O3S/c5-10(7,8)6-1-3-9-4-2-6/h1-4H2,(H2,5,7,8)

Upstream product

• 110-91-8 morpholine 
• 1048017-38-4 benzyl (morpholin-4-ylsulfonyl)carbamate 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 1828-66-6 morpholine-4-sulfonyl chloride 
• 861397-54-8 Boc-morpholine-4-sulfonic acid amide 
• 108555-00-6 4-nitrophenyl sulfamate 

Downstream Products

• 92-53-5 4-Phenylmorpholine 
• 90470-88-5 Morpholine-4-sulfonic acid phenylamide 
• 115921-02-3 Morpholine-4-sulfonic acid (2-nitro-phenyl)-amide 
• 99168-83-9 N-(4-nitrophenyl)morpholine-4-sulfonamide 
• 1025765-34-7 C₂₃H₂₃FN₄O₄S 
• 1127234-81-4 13-cyclohexyl-3-methoxy-6-(4-(4-morpholinylcarbonyl)-1,3-oxazol-5-yl)-N-(4-morpholinylsulfonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide 
• 914606-94-3 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine-4-sulfamide 
• 90470-89-6 N-(3-chlorophenyl)morpholine-4-sulfamide 
• 90470-87-4 N-(3-methoxyphenyl)morpholine-4-sulfamide 

Relevant articles and documents

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms hCA IX and XII was co-crystalized with hCA II showing significant potential for fragment periphery evolution via fragment growth and linking. These opportunities will be identified in the future via the screening of this fragment structure for co-operative carbonic anhydrase binding with other structurally diverse fragments.

Photochemically Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverages a dual-catalytic system, with [Ir(ppy)2(dtbbpy)]PF6 as a photosensitizer, NiBr2·glyme as a precatalyst, and 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU)

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independe