260047-11-8Relevant articles and documents
Straightforward transformation of isoxazoles into pyrazoles: renewed and improved
Sviridov, Sergey I.,Vasil'ev, Andrei A.,Shorshnev, Sergey V.
, p. 12195 - 12201 (2008/02/11)
Isoxazoles bearing alkyl or carbamoyl groups were transformed into the corresponding pyrazoles in high yields by the treatment with hydrazine in methanol in the presence of a hydrogenation catalyst, e.g., Raney nickel, at ambient temperature. For the synthesis of N-substituted pyrazoles, hydrogenolysis of isoxazole followed by the treatment with substituted hydrazine was required. 3(5)-Aryl- or acylamido-substituted isoxazoles are less suitable for such transformations.
