260054-41-9Relevant academic research and scientific papers
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: Identification and optimisation of substituted 4,6-Bis anilino pyrimidines
Beattie, John F.,Breault, Gloria A.,Ellston, Rebecca P. A.,Green, Stephen,Jewsbury, Philip J.,Midgley, Catherine J.,Naven, Russell T.,Minshull, Claire A.,Pauptit, Richard A.,Tucker, Julie A.,Pease, J. Elizabeth
, p. 2955 - 2960 (2007/10/03)
Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.
