260246-17-1

Basic information

• Product Name: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER
• Synonyms: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER;3-FLUORO-BETA-OXO-BENZENEPROPANOIC ACID METHYL ESTER;METHYL 3-FLUOROBENZOYLACETATE;3-Fluoro-b-oxo-benzenepropanoic acid Methyl ester;Methyl 3-(3-fluorophenyl)-3-oxopropanoate
• CAS NO: 260246-17-1
• Molecular Formula: C10H9FO3
• Molecular Weight: 196.18
• Mol File: 260246-17-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 83°C/0.15mm
• Appearance: /
• Density: 1.213±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.08±0.46(Predicted)
• CAS DataBase Reference: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(260246-17-1)
• EPA Substance Registry System: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER(260246-17-1)

Safety Data

• Hazardous Substances Data: 260246-17-1(Hazardous Substances Data)

Usage

General Description

3-(3-fluoro-phenyl)-3-oxo-propionic acid methyl ester is a chemical compound with the molecular formula C11H9FO3. It is a methyl ester derivative of 3-(3-fluoro-phenyl)-3-oxo-propionic acid. 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER is often used in pharmaceutical research and drug development due to its potential medical applications. Its precise uses and properties are not widely documented, but its existence indicates its potential importance in the field of medicinal chemistry and pharmacology. Further research and investigation into its properties and potential applications are warranted to fully understand its significance.

Upstream product

• 616-38-6 carbonic acid dimethyl ester 
• 455-36-7 1-(3-fluorophenyl)ethanone 

Downstream Products

• 1454691-31-6 (R)-(+)-methyl 3-(acetyloxy)-3-(3-fluorophenyl)propanoate 
• 1454691-22-5 methyl 3-(acetyloxy)-3-(3-fluorophenyl)propanoate 
• 1454691-18-9 methyl 3-(3-fluorophenyl)-3-hydroxypropanoate 
• 51699-47-9 1-(3-fluorophenyl)-1,3-propanediol 
• 51699-42-4 ethyl 3-(3-fluorophenyl)-3-hydroxypropanoate 

Relevant articles and documents

Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis

The heterodimeric transmembrane αv integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyrate-based antagonists of the vitronectin receptors αvβ3 and αvβ5 significantly change the biological activities against αvβ6 and αvβ8. This resulted in the discovery of a pan αv antagonist (compound 39, 4-40 nM for the integrin receptors named above) possessing excellent oral pharmacokinetic properties in rats (with a clearance of 7.6 mL/(min kg) and a bioavailability of 97%).

SUBSTITUTED OXAZOLE- AND THIAZOLE-BASED CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS II

The invention relates to oxazole and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Baccatin derivatives and a process for producing the same

The object of the invention is to develop baccatin derivatives useful for preparing taxoid compounds such as paclitaxel and a process for the producing the same. The invention provides baccatin derivatives represented by the general formula (I) as well as a process for producing baccatin derivatives represented by the general formula (I) above, which comprises allowing a baccatin represented by the general formula (II) to react with a β-ketoester in the absence of a catalyst or in the presence of a tin compound or an amine base, preferably under reduced pressure.