260250-88-2Relevant academic research and scientific papers
EPSP SYNTHASE: THE DESIGN AND SYNTHESIS OF BISUBSTRATE INHIBITORS INCORPORATING NOVEL 3-PHOSPHATE MIMICS
Sikorski, James A.,Miller, Michael J.,Braccolino, Diane S.,Cleary, Darryl G.,Corey, Susan D.,et al.
, p. 115 - 118 (2007/10/02)
Novel aromatic bisubstrate inhibitors of the enzyme EPSP (5-enolpyruvoylshikimate-3-phosphate) synthase (EC 2.5.1.19) have been designed and synthesized as structural analogs of the single, catalytic intermediate 1 utilized by the enzyme.These aromatic inhibitors incorporate novel α-hydroxyphosphonates, malonate ethers and α-hydroxymalonates as replacements for the hydrolytically labile 3-phosphate group.These 3-phosphate mimics were much preferred to the corresponding methylene and vinylic phosphonates, malonates and phosphonomethyl ethers.
