260258-97-7Relevant academic research and scientific papers
Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR
Bilodeau, Mark T.,Cunningham, April M.,Koester, Timothy J.,Ciecko, Patrice A.,Coll, Kathleen E.,Huckle, William R.,Hungate, Randall W.,Kendall, Richard L.,McFall, Rosemary C.,Mao, Xianzhi,Rutledge, Ruth Z.,Thomas, Kenneth A.
, p. 2485 - 2488 (2007/10/03)
1,5-Diarylbenzimidazoles have been identified as potent inhibitors of KDR kinase activity. The series was developed with a goal of finding compounds with optimal drug-like properties. This communication describes structural modifications in the series that enhance solubility, lower protein binding, and provide compounds with excellent potency and pharmacokinetic profiles.
