260267-07-0

Basic information

• Product Name: 5,6-Difluoro-1H-indole-3-carboxaldehyde
• Synonyms: 5,6-Difluoro-1H-indole-3-carboxaldehyde;5,6-Difluoro-1Hindole-3-carbaldehyde;5,6-difluoroindole-3-carboxaldehyde;5,6-difluoroindole-3-carbaldehyde
• CAS NO: 260267-07-0
• Molecular Formula: C₉H₅F₂NO
• Molecular Weight: 181.14
• Mol File: 260267-07-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 348.2 °C at 760 mmHg
• Flash Point: 164.4 °C
• Appearance: /
• Density: 1.485
• PKA: 14.06±0.30(Predicted)
• CAS DataBase Reference: 5,6-Difluoro-1H-indole-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Difluoro-1H-indole-3-carboxaldehyde(260267-07-0)
• EPA Substance Registry System: 5,6-Difluoro-1H-indole-3-carboxaldehyde(260267-07-0)

Safety Data

• Hazardous Substances Data: 260267-07-0(Hazardous Substances Data)

Usage

General Description

5,6-Difluoro-1H-indole-3-carboxaldehyde is a chemical compound with the molecular formula C9H6F2NO. It belongs to the class of indole carboxaldehydes and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5,6-Difluoro-1H-indole-3-carboxaldehyde is a pale yellow to brownish crystalline powder with a melting point of 60-64°C. It is known for its strong and unique odor which can be described as floral, animal-like, and green. 5,6-Difluoro-1H-indole-3-carboxaldehyde is mainly utilized in the synthesis of various biologically active compounds and has found applications in the development of new drugs with potential therapeutic uses. It is important to handle this compound with caution and adhere to all safety protocols when working with it in a laboratory setting.

Upstream product

• 169674-01-5 5,6-difluoro-1H-indole 
• 2927-34-6 3,4-difluorotoluene 
• 468718-05-0 3,4-difluoro-5-nitrotoluene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 468718-07-2 5,6-difluoro-1-(toluene-4-sulfonyl)-1H-indole-3-carbaldehyde 

Relevant articles and documents

INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)

The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.

3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I) wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.