26031-66-3

Upstream product

• 110-86-1 pyridine 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 74266-42-5 1-(4-chlorophenyl)-2,2-bis(4-(dimethylamino)phenyl)ethanone 
• 23071-71-8 1-(4-Dimethylaminophenylimino-)-2-keto-2-(4-chlorphenyl-)-propionitril 
• 52626-24-1 1-(4-chloro-phenyl)-2-[(Z)-(4-dimethylamino-phenyl)-oxy-imino]-ethanone 
• 78938-15-5 [6-(4-Chloro-benzoyl)-1,4-di-pyridin-3-yl-1,4-dihydro-[1,2,4,5]tetrazin-3-yl]-(4-chloro-phenyl)-methanone 
• 73910-93-7 2-(4-chloro-phenyl)-4,6-bis-(4-methoxy-phenyl)-pyridine 
• 72666-43-4 2,6-bis(4-chlorophenyl)-4-phenylpyridine 
• 73910-97-1 4-[2,6-bis(4-chlorophenyl)pyridin-4-yl]-N,N-dimethylbenzenamine 
• 127635-96-5 2-(4'-chlorophenacyl)-3-phenylthio-1,4-naphthoquinone 
• 75573-16-9 2,6-Bis-(4-chloro-phenyl)-4-(3,4-dimethoxy-phenyl)-pyridine 
• 72666-45-6 4-Benzo[1,3]dioxol-5-yl-2,6-bis-(4-chloro-phenyl)-pyridine 
• 105686-78-0 2-(4-Chloro-phenyl)-6-phenyl-4-(3,4,5-trimethoxy-phenyl)-pyridine 
• 78121-85-4 2-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-6-p-tolyl-pyridine 
• 73910-92-6 2-(4-chloro-phenyl)-4-(3,4-dimethoxy-phenyl)-6-(4-methoxy-phenyl)-pyridine 
• 129155-22-2 2-(4'-chlorophenacyl)-3-ethylthio-1,4-naphthoquinone 

Relevant academic research and scientific papers

Selective hydrolysis of 1-cyanocyclopropane-1-carboxylates: Concise preparation of 1-carbamoylcyclopropane-1-carboxylates

An efficient and straightforward method has been developed for the preparation of 1-carbamoylcyclopropane-1-carboxylate derivatives selective hydrolysis of 1-cyanocyclopropane-1-carboxylates by using hydroxylamine and sodium acetate system strategy. The of 1-carbamoylcyclopropane-1-carboxylate 2a was further confirmed by X-ray single crystal analysis.

Pyridinium ylide assisted highly stereoselective one-pot synthesis of trans-2-(4-chlorobenzoyl)-3-aryl-spiro[cyclopropane-1,2'-inden]-1',3'-diones and their antimicrobial and nematicidal activities

A series of highly stereoselective polysubstituted cyclopropane derivatives were synthesized via one-pot two-step tandem reaction starting from pyridine, 4-chloro phenacyl bromide, 1,3-indandione and aromatic aldehydes in acetonitrile using triethylamine

1,2-Dicarbofunctionalization of Trifluoromethyl Alkenes with Pyridinium Salts via a Cycloaddition/Visible-Light-Enabled Fragmentation Cascade

Although trifluoromethyl alkenes have great synthetic potential, their 1,2-difunctionalization has been a challenge. In this Letter, we disclose the first 1,2-dicarbofunctionalization of trifluoromethyl alkenes with pyridinium salts via a cascade process

Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in?vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

An efficient microwave accelerated three component reaction of phenacyl azides and pyridinium phenacyl salts: A facile greener approach to 2-amino-2-ene-1,4-diones/pyrrolidin-2-ones

A mild and efficient base promoted, microwave assisted, green synthesis of 2-amino-2-ene-1,4-diones has been described by the decomposition of phenacyl azides followed by treatment with pyridinium salts of phenacyl bromides in aqueous media. A diverse range of substrates bearing electron-releasing and electron-withdrawing substituents were well tolerated and delivered corresponding 2-amino-2-ene-1,4-diones in good yields. Synthesized 2-amino-2-ene-1,4-diones have been further explored in the synthesis of various substituted 4-hydroxypyrrolidin-2-ones.

Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: a facile access to indolizine scaffolds

An expedient and transition-metal-free synthetic strategy has been developed for the construction of substituted indolizines from a unique combination of pyridinium salts and 2-bromoallyl sulfones. This approach does not compromise with the diverse substitutions on both the pyridinium salts and 2-bromoallyl sulfones. Wide substrate scope, operational simplicity, milder reaction conditions and good to moderate yields are the merits associated with the current approach. Moreover, this method provides two products which are amenable for the generation of a library of key indolizine building blocks. This journal is

DMAP-Catalyzed Annulation Approach for Modular Assembly of Furan-Fused Chromenes

With a tandem DMAP-catalyzed reaction between o-AQM, in which it is generated in situ from propargylic amine, and acyl carbene surrogate (from pyridinium ylide), a variety of polyarylated chromenes are assembled in good yields. This process does not require transition-metal catalyst and exhibits easy manipulation of the arene group and good functional group compatibility, particularly the -Br group which can be further transformed to other functionalities by cross-coupling reactions. The modular feature of o-AQM substrates and the simple operation procedures add further advantages to this synthetic method.

A metal-free approach for the synthesis of amides/esters with pyridinium salts of phenacyl bromides via oxidative C–C bond cleavage

An efficient, simple, and metal-free synthetic approach for the N- and O-benzoylation of various amines/benzyl alcohols with pyridinium salts of phenacyl bromides is demonstrated to generate the corresponding amides and esters. This protocol facilitates the oxidative cleavage of a C–C bond followed by formation of a new C–N/C–O bond in the presence of K2CO3. Various pyridinium salts of phenacyl bromides can be readily transformed into a variety of amides and esters which is an alternative method for the conventional amidation and esterification in organic synthesis. High functional group tolerance, broad substrate scope and operational simplicity are the prominent advantages of the current protocol.

Unexpected reactivity of pyridinium salts toward alkynyl Fischer complexes to produce oxo-heterocycles

The unprecedented reaction of ketone-containing aromatic pyridinium salts 3a-e and alkynyl Fischer complexes 1a-f proceeds via a mild domino process to provide 4,6-disubstituted pyran-2-ones 5a-k and 2,3,5-trisubstituted furans 6a-h (45-97%). According of the results of isotopic labeling experiments, a mechanism involving an initial Michael addition appears to be the key step, obtaining a mesomeric structure responsible for the formation of both products.