260353-67-1

Upstream product

• 321903-56-4 ethyl (+)-(1S,5S,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate 
• 260353-92-2 N-(R)-1-phenylethyl-(1R,2S,5R,6S)-2-spiro-5'-hydantoin-4,4-ethylenedithio-6-fluorobicyclo[3.1.0]hexane-6-carboxylamide 
• 321903-38-2 N-(R)-1-phenylethyl-(1S,2R,5S,6R)-2-spiro-5'-hydantoin-4,4-ethylenedithio-6-fluorobicyclo[3.1.0]hexane-6-carboxylamide 
• 321903-65-5 ethyl (1R,5R,6S)-4,4-ethylendithio-6-fluoro-oxobicyclo[3.1.0]hexane-6-carboxylate 

Relevant academic research and scientific papers

6-fluorobicyclo[3.1.0]hexane derivatives

The present invention provides fluorobicyclo[3.1.0]hexane derivatives represented by the formula [wherein R1and R2are the same or different and each represents a hydrogen atom, a C1-10alkyl group, a C3-8cycloalk

Synthesis, SARs, and pharmacological characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists

(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (4, LY354740), a highly selective and orally active group II metabotropic glutamate receptor (mGluR) agonist, has increased interest in the study of group II mGluRs. Our interest focused on a conformat