260354-82-3Relevant academic research and scientific papers
A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis
Siu, Jason,Baxendale, Ian R.,Lewthwaite, Russell A.,Ley, Steven V.
, p. 3140 - 3160 (2007/10/03)
In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic 'catch and release' methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-bound copper(II) species. Utilising this approach we are able to derive many of the same benefits associated with both solid phase synthesis and supported reagent methods. The Royal Society of Chemistry 2005.
Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: Synthesis and muscarinic activity
Dannhardt,Kiefer,Lambrecht,Laufer,Mutschler,Schweiger,Striegel
, p. 839 - 850 (2007/10/03)
A series of 3-, 4- and 5-aminomethyl isoxazoles and isoxazoles with one or two additional methyl groups at the heterocycle were synthesized in order to investigate the structural requirements, ie heterocyclic moiety, regiochemistry and length of an aminoalkyl unit, for muscarinic activity. This was assayed on isolated rabbit vas deferens (M1 receptor subtype) and isolated guinea-pig atrium (M2 receptor subtype) and ileum (M3 receptor subtype). The isoxazoles tested are one to three orders of magnitude less active than furane or oxadiazole derivatives, having similar structural characteristics except for the heterocycle. Thus, the differences in molecular point charges and charge distribution contribute to the muscarinic activity of these compounds more than small differences in molecular shape and conformational energies.
