260359-31-7Relevant academic research and scientific papers
Visible-Light-Induced Radical Cascade Reaction of 1-Allyl-2-ethynylbenzoimidazoles with Thiosulfonates to Assemble Thiosulfonylated Pyrrolo[1,2-a]benzimidazoles
Liu, Yan,Zhang, Niuniu,Xu, Yanli,Chen, Yanyan
, p. 16882 - 16891 (2021/11/18)
A visible-light-induced radical domino reaction of 1-allyl-2-ethynylbenzoimidazoles with thiosulfonates was developed, which generated the thiosulfonylated pyrrolo[1,2-a]benzimidazoles in moderate to good yields. This reaction proceeded under transition-metal-free conditions with good functional group tolerance and high regioselectivity. The possible pathway involved thiosulfonates were activated through the energy transfer route promoted by photocatalysis.
Nickel-catalysed dehydrogenative coupling of aromatic diamines with alcohols: Selective synthesis of substituted benzimidazoles and quinoxalines
Bera, Atanu,Sk, Motahar,Singh, Khushboo,Banerjee, Debasis
supporting information, p. 5958 - 5961 (2019/05/27)
The first nickel-catalysed dehydrogenative coupling of primary alcohols and ethylene glycol with aromatic diamines for selective synthesis of mono- and di-substituted benzimidazoles and quinoxalines is reported. The earth-abundant, non-precious and simple NiCl2/L1 system enables the synthesis of N-heterocycles releasing water and hydrogen gas as byproducts. Mechanistic studies involving deuterium labeling experiments and quantitative determination of hydrogen gas evaluation were performed.
DUAL ACTING FKBP12 AND FKBP52 INHIBITORS
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Page/Page column 33; 48, (2019/03/12)
Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.
Synthesis and thermolysis of heterocyclic 3-aza-3-ene-1,5-diynes(1).
Nadipuram, Asha K,David, Wendi M,Kumar, Dalip,Kerwin, Sean M
, p. 4543 - 4546 (2007/10/03)
[reaction: see text] Simple, acyclic 3-aza-3-ene-1,5-diynes undergo an aza-Bergman rearrangement to a fleeting 2,5-didehydropyridine (2,5-ddp) intermediate that rapidly ring-opens to beta-alkynylacrylonitrile products. In an effort to access longer-lived 2,5-ddp intermediates, we have prepared heterocyclic 3-aza-3-ene-1,5-diynes. The thermolysis of one such heterocyclic aza-enediyne does not afford products derived from trapping a 2,5-ddp intermediate but rather cyclopropanes that appear to arise from a carbene intermediate and a product that appears to be a trapping product from a 2,3-ddp intermediate.
Condensation of o-phenylenediamine with phenylpropiolic acid
Dubey,Kumar, Ramesh,Grossert,Hooper
, p. 1041 - 1045 (2007/10/03)
Attempted condensation of o-phenylenediamine with phenytpropiolic acid with a view to preparing 2-β-phenylacetylenylbenzimidazole under a variety of conditions such as in refluxing methanol, in hot PPA, in refluxing benzene with Dean-stark removal of water etc., leads to the recovery of starting materials. However, condensation of o-phenylenediamine dihydrochloride and dihydrobromides with phenylpropiolic acid in refluxing ethylene glycol yield the respective 2-haloarylvinylbenzimidazoles. The latter are dehydrohalogenated under basic conditions to obtain the desired 2β- phenylacetylenylbenzimidazole. The mechanism of formation of 2- haloaryivinylbenzimidazoles has been discussed.
Synthesis of N-phenyl-substituted derivatives of morphine alkaloids
Moiseev,Bakhanova,Schmidhammer,Kalinin
, p. 589 - 592 (2007/10/03)
A method for the preparation of N-phenyl-substituted morphine alkaloids by treatment of the corresponding N-nor derivatives with Ph3Bi in the presence of Cu(OAc)2 is proposed. 17-Nor-17-phenylthebaine thus obtained can serve as a convenient starting material for the preparation of other N-phenyl-substituted alkaloids.
