26037-60-5Relevant academic research and scientific papers
Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors
Lee, Kyeong,Cho, Soo Hyun,Lee, Jee Hyun,Goo, Jail,Lee, Sung Yoon,Boovanahalli, Shanthaveerappa K.,Yeo, Siok Koon,Lee, Sung-Joon,Kim, Young Kook,Kim, Dong Hee,Choi, Yongseok,Song, Gyu-Yong
, p. 515 - 525 (2013)
We report a new series of naphthoquinone derivatives as potent ACAT inhibitors, which were obtained through structural variations of previously disclosed lead 1. Several analogs represented by 3i-l, 4k-m, 6a-n, 7a, and 7i demonstrated potent human macrophage ACAT inhibitory activity by a cell-based reporter assay with human HepG2 cell lines. In particular, compounds 4l and 6j emerged as highly potent inhibitors, exhibiting significantly high inhibitory potencies with IC50 values of 0.44 μM and 0.6 μM, respectively. Moreover, compound 4l significantly reduced the accumulation of cellular cholesterol in HepG2 cell lines.
Synthesis method of thioether compound containing 1,4-naphthoquinone structure
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Paragraph 0013; 0024-0031, (2020/05/30)
The invention belongs to the technical field of organic chemical synthesis, and discloses a synthesis method of a thioether compound containing a 1,4-naphthoquinone structure; the thioether compound containing the 1,4-naphthoquinone structure is prepared by carrying out a reaction on a tetralone compound with a sulfoxide compound under the catalytic action of iodine, the reaction temperature is 60-100 DEG C, and the reaction time is 6-24 h. Compared with a synthesis method in the prior art, the method has the advantages that the naphtholone compound which is cheap, easy to obtain, wide in source, stable and low in toxicity and the low-toxicity odorless sulfoxide compound can be used for generating the thioether compound containing the 1,4-naphthoquinone structure through one-step reaction,the requirement for green chemistry is met, the requirement of the method on reaction conditions is low, and the yield of the obtained product is relatively high.
I2-promoted selective oxidative cross-coupling/annulation of 2-naphthols with methyl ketones: A strategy to build naphtho[2,1- b ]furan-1(2 H)-ones with a quaternary center
Gao, Qinghe,Wu, Xia,Liu, Shan,Wu, Anxin
supporting information, p. 1732 - 1735 (2014/04/17)
A highly efficient and selective molecular iodine-promoted oxidative cross-coupling/annulation between 2-naphthols and methyl ketones has been realized. The reaction successfully constructed a new quaternary carbon center within 3(2H)-furanones. Our synth
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
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Page/Page column 9, (2012/02/01)
Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective t
Anticancer prodrug studies: DielsAlder chemistry of 1-methylthio-1-(p- tolylsulfonyl)ethene
Pratt, Andrew J.,Rendle, Phillip M.,Steel, Peter J.
experimental part, p. 945 - 950 (2012/08/27)
The reactivity of 1-methylthio-1-(p-tolylsulfonyl)ethene (1) as a dienophile in DielsAlder chemistry is investigated. Cycloaddition reactions were carried out with a range of pyran-2-ones and isobenzofurans. The initial DielsAlder adducts have the potenti
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
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Page/Page column 14, (2011/11/01)
Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective t
