260390-87-2Relevant academic research and scientific papers
A convenient method to synthesize phosphinic peptides containing an aspartyl or glutamyl aminophosphinic acid. Use of the phenyl group as the carboxyl synthon
Georgiadis, Dimitris,Matziari, Magdalini,Vassiliou, Stamatia,Dive, Vincent,Yiotakis, Athanasios
, p. 14635 - 14648 (2007/10/03)
Many attempts to synthesize AspΨ(PO2CH2)Ala phosphinic pseudodipeptides by Michael addition of aspartyl aminophosphinic acid to ethyl methacrylate have failed. The preparation of such phosphinic peptides was finally achieved starting from a protected PheΨ(PO2CH2)Ala phosphinic building block. The key step is a mild oxidation of the phenyl group to carboxylic acid by use of the ruthenium trichloride-sodium metaperiodate system.
