260391-72-8Relevant articles and documents
Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug
Berry, Jane M.,Howard, Philip W.,Kelland, Lloyd R.,Thurston, David E.
, p. 1413 - 1416 (2007/10/03)
The first example of an N10-protected (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protected PBD prodrugs.