260413-67-0

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 870-63-3 prenyl bromide 
• 556-82-1 3-methyl-2-buten-1-ol 
• 50874-14-1 phenylpropargyl bromide 

Downstream Products

• 1158072-90-2 4-(4-nitrobenzyl)-2,3-dihydro-5-phenyl-3-(prop-1-en-2-yl)furan 
• 1158072-85-5 C₂₆H₃₀O₃ 
• 1158072-83-3 3-allyl-4-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)-5,5-dimethylfuran-2(5H)-one 
• 1158072-94-6 4-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)benzonitrile 
• 1158072-80-0 3-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)cyclopent-2-enone 
• 1158072-66-2 3-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)-2-methylcyclohex-2-enone 
• 1158073-04-1 C₂₁H₂₄O₂ 
• 1158072-82-2 4-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)-3,5,5-trimethylfuran-2(5H)-one 
• 1158072-73-1 2-allyl-3-((4,5-dihydro-2-phenyl-4-(prop-1-en-2-yl)furan-3-yl)methyl)cyclohex-2-enone 

Relevant academic research and scientific papers

Alkene-directed N-attack chemoselectivity in the gold-catalyzed [2+2+1]-annulations of 1,6-enynes with N-hydroxyanilines

Kinetically unstable nitrones are generated from gold-catalyzed reactions of 1,6-enynes with N-hydroxyanilines, and subsequently trapped by tethered alkenes to furnish [2+2+1]-annulations. Our experimental data reveal that such nitrones arise from atypical N-attack chemoselectivity that is triggered by tethered alkenes to facilitate the key protodeauration reaction. Kinetically unstable nitrones are generated from gold-catalyzed reactions of 1,6-enynes with N-hydroxyanilines, and subsequently trapped by tethered alkenes to furnish [2+2+1]-annulations. These findings open the door to new ways to access ketone nitrones with good stereoselectivity.

Unexpected Pd-catalyzed coupling, propargyl-allenyl isomerization and Alder-ene reaction: Facile synthesis of some not readily available 2,3-dihydrofuran derivatives

(Chemical Equation Presented) An interesting sequential reaction involving Pd-catalyzed coupling, propargyl-allenyl isomerization, and Alder-ene cycloaddition is reported, providing a facile synthesis of some not readily available 2,3-dihydrofurans from e

Synthesis, structure and emission properties of spirocyclic benzofuranones and dihydroindolones: A domino insertion-coupling-isomerization-Diels-Alder approach to rigid fluorophores

An alkynoyl ortho-iodo phenolester or alkynoyl ortho-iodo anilides and propargyl allyl ethers react under Sonogashira coupling conditions in the sense of an insertion-coupling-isomerization-Diels-Alder hetero domino reaction to furnish (tetrahydroisobenzo

Mechanistic dichotomy in CpRu(CH3CN)3PF6 catalyzed enyne cycloisomerizations

Enynes are easily accessible building blocks as a result of the rich chemistry of alkynes and thus represent attractive substrates for ring formation, A ruthenium catalyst for cycloisomerization effects such reaction of 1,6- and 1,7-enynes typically at room temperature in acetone or DMF under neutral conditions. The reaction is effective for forming five- and six-membered rings of widely divergent structure. The alkyne may bear both election-donating and election-withdrawing substituents. The alkene may be di- or trisubstituted. Introduction of a quaternary center at the propargylic position of an ynoate, however, completely changes the nature of the reaction. In the case of a 1,6-enynoate, a seven-membered ring forms in excellent yield under equally mild conditions. Evidence is presented to indicate a complete change in mechanism. In the former case, the reaction involves the intermediacy of a ruthenacyclopentene. In the latter case, a C-H insertion to form a π-allylruthenium intermediate is proposed and supported by deuterium-labeling studies. A rationale is presented for the structural dependence of the mechanism.