260417-71-8Relevant academic research and scientific papers
Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines
Gregson, Stephen J.,Howard, Philip W.,Barcella, Simona,Nakamya, Anthonia,Jenkins, Terence C.,Kelland, Lloyd R.,Thurston, David E.
, p. 1849 - 1851 (2007/10/03)
A series of novel C2/C3-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via cleavage of the N10-Alloc protecting group from appropriate precursors. Biophysical and biological evaluations show that the presence of C2/C3-endo unsaturation in the PBD C-ring enhances both DNA-binding reactivity and in vitro cytotoxic potency. (C) 2000 Elsevier Science Ltd. All rights reserved.
