260417-85-4

Upstream product

• 260417-82-1 (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-4-(2-acetyloxyethyl)-2-(tert-butyldimethylsilyloxymethyl)-2,3-dihydropyrrole 
• 260417-80-9 (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-2-(tert-butyldimethylsilyloxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole 
• 260417-81-0 (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-2-(tert-butyldimethylsilyloxymethyl)-4-(2-hydroxyethyl)-2,3-dihydropyrrole 
• 260417-69-4 {5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester 
• 260417-83-2 (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-4-(2-acetyloxyethyl)-2-(hydroxymethyl)-2,3-dihydropyrrole 

Downstream Products

• 260543-56-4 (11aS)-8-benzyloxy-2-(2-hydroxyethyl)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 

Relevant academic research and scientific papers

Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

A series of novel C2/C3-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via cleavage of the N10-Alloc protecting group from appropriate precursors. Biophysical and biological evaluations show that the presence of C2/C3-endo unsaturation in the PBD C-ring enhances both DNA-binding reactivity and in vitro cytotoxic potency. (C) 2000 Elsevier Science Ltd. All rights reserved.