260441-08-5Relevant academic research and scientific papers
Copper-Catalyzed Propargylation of Nitroalkanes
Kim, Raphael S.,Dinh-Nguyen, Linh V.,Shimkin, Kirk W.,Watson, Donald A.
supporting information, p. 8106 - 8110 (2020/11/02)
Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient α-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these α-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered N-heterocycles such as pyrroles and 2-pyrrolines.
Arylpiperazines and their use as metalloproteinase inhibiting agents (MMP)
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Page/Page column 16; 17, (2010/02/06)
Arylpiperazines of formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
