260441-81-4

Usage

Uses

Used in Carbohydrate Chemistry Research:
2,3:5,6-bis-O-(1-Methylethylidene)-D-gulose oxime is used as a reagent in carbohydrate chemistry for its ability to facilitate the formation of glycosidic linkages, which are crucial in the synthesis of complex carbohydrate structures.
Used in Organic Chemistry:
In the field of organic chemistry, 2,3:5,6-bis-O-(1-Methylethylidene)-D-gulose oxime serves as a protecting group, which is essential in the synthesis of intricate carbohydrate molecules to prevent unwanted reactions from occurring at certain functional groups.
Used in Drug Development:
The unique structure and properties of 2,3:5,6-bis-O-(1-Methylethylidene)-D-gulose oxime make it a valuable compound for the development of new drugs, particularly in the fields of chemistry and biochemistry, where its specific interactions with biological systems can be harnessed for therapeutic purposes.
Used in Material Science:
Its potential applications extend to material science, where the compound may be utilized in the creation of new materials with specific properties,得益于其独特的化学结构和反应性。

InChI:InChI=1/C12H21NO6/c1-11(2)16-6-8(18-11)9(14)10-7(5-13-15)17-12(3,4)19-10/h5,7-10,14-15H,6H2,1-4H3/b13-5+/t7-,8+,9-,10-/m0/s1

Upstream product

• 6322-07-2 D-gulono-1,4-lactone 
• 34685-42-2 (3aR,6S,6aR)-6-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol 
• 78039-12-0 (3aR,4R,6S,6aR)-6-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydro-furo[3,4-d][1,3]dioxol-4-ol 

Downstream Products

• 1421359-74-1 C₃₄H₅₀N₂O₁₃ 
• 1421359-92-3 C₂₆H₃₇NO₉S 
• 1421360-27-1 methyl (3R,5R)-N-(2,3:5,6-di-O-isopropylidene-β-D-gulofuranosyl)-5-methoxy-3-phenylisoxazolidine-5-carboxylate 
• 1421360-25-9 methyl (3S,5R)-3-benzyl-N-(2,3:5,6-di-O-isopropylidene-β-D-gulofuranosyl)-5-methoxyisoxazolidine-5-carboxylate 
• 1421360-35-1 methyl (3S,5R)-3-[3-(benzoyloxy)propyl]-N-(2,3:5,6-di-O-isopropylidene-β-D-gulofuranosyl)-5-methoxyisoxazolidine-5-carboxylate 
• 1421359-94-5 C₂₆H₃₇NO₁₀S 
• 35023-80-4 (Z)-2,3:5,6-di-O-isopropylidene-D-gulose oxime 
• 1370639-67-0 C₂₈H₄₃NO₉ 
• 117770-16-8 1,4-dideoxy-1,4-imino-D-allitol hydrochloride 

Relevant academic research and scientific papers

Conjugate of cytotoxin molecule and cell binding receptor molecule

A conjugate of a strong cytotoxin molecule and a cell binding receptor molecule has a structure shown in a molecular formula (I), wherein T, L, m, n, -----, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are defined in the text. The conjugate is used for treating cancer, immunological diseases and infectious diseases.

CONJUGATE OF CELL-BINDING RECEPTOR WITH CYTOTOXIC AGENT

PROBLEM TO BE SOLVED: To provide a conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule for targeted treatment. SOLUTION: According to the present invention, there is provided a conjugate having a structure of formula (I) and a pharmaceutical acceptable salt and a solvate thereof. The conjugate is used for treating cancer, autoimmune disease, and infectious disease. (T is a targeting or binding ligand; L is a releasable linker; a broken line is a linkage bond that L connects to a molecule inside the bracket independently; n is an integer of 1 to 20; m is an integer of 1 to 10; and a structure in parentheses is a potent antimitotic agent/drug.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors

Synthetic studies of two components of tubulysins, tubulin polymerization inhibitors are described. The highly stereoselective synthesis of tubuvaline methyl ester (2) was accomplished by 1,3-dipolar cycloaddition of nitrone d-6 and acrylic acid derivativ

Potential Glycosidase Inhibitors: Synthesis of 1,4-Dideoxy-1,4-imino Derivatives of D-Glucitol, D- and L-Xylitol, D- and L-Allitol, D- and L-Talitol, and D-Gulitol

Conversion of 2,3,5,6-tetra-O-benzyl-D-galactofuranose (19) into its oxime and subsequent treatment with methanesulphonyl chloride gave 2,3,5,6-tetra-O-benzyl-4-O-methylsulphonyl-D-galactonitrile (21).Reductive cyclization by sodium borohydride/cobalt(II)