26046-94-6

Usage

Uses

Used in Pharmaceutical Industry:
Plantaginin is used as a therapeutic agent for its anti-inflammatory, antioxidant, and immune-modulating properties, making it suitable for treating various health conditions such as respiratory infections, gastrointestinal disorders, and skin irritations.
Used in Antimicrobial Applications:
Plantaginin is used as an antibacterial and antiviral agent, demonstrating its potential in the development of new pharmaceuticals to combat infections.
Used in Oncology Research:
Plantaginin is used as a subject of research in the field of oncology due to its potential anti-cancer effects, with further studies needed to explore its therapeutic applications in cancer treatment.

Upstream product

• 604-69-3 β-D-glucose pentaacetate 
• 1180-46-7 4,5,6,7-tetra-O-acetylflavone 
• 33507-93-6 7-hydroxy-5,6-diacetoxy-2-(4'-acetoxyphenyl)-4H-1-benzopyran-4-one 

Downstream Products

• 2280-44-6 D-Glucose 
• 529-53-3 scutellarein 

Relevant academic research and scientific papers

Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin

Natural flavonoids and flavonoid glycosides exist in many plants and have been demonstrated to possess various clinically relevant properties, isolating large amounts of these compounds that have striking structural similarity from plant sources needs tedious isolation techniques. These processes limited their availability in structural diversity for structure?activity relationship (SAR) studies, and restrict large quantities for, as an example, their mechanistic evaluation of the in vivo activities. In this work, we developed a semi-synthetic strategy from scutellarin for the synthesis of a series of natural flavonoids and flavonoid glycosides. By taking this strategy, eight bioactive flavonoids with striking structural similarities were synthesized efficiently and practically. The sufficient amounts obtained products will greatly facilitate the SAR studies and mechanistic evaluation of the in vivo activities.

Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo

Based on metabolic mechanism of scutellarin in vivo that scutellarin could be hydrolyzed into scutellarein by β-glucuronide enzyme, some glucose-containing scutellarein derivatives were designed and synthesized through the introduction of glucose moiety at C-7 position of scutellarein via a glucosidic bond. Biological activity evaluation showed that these glucose-containing scutellarein derivatives exhibited potent DPPH radical scavenging activities. Furthermore, the improvement of physicochemical properties such as anticoagulant and neuroprotective activities alongside with the water solubility was achieved by introducing glucose. These findings suggest that the introduction of the glucose moiety to scutellarein wattants further development of this kind of compounds as neuroprotective agents.