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4-(4-nitro-benzylidene)-1-propyl-1,4-dihydro-pyridine is a complex organic chemical compound with the molecular formula C18H18N2O2. It is a derivative of 1,4-dihydropyridine, which is a class of compounds known for their potential applications in pharmaceuticals, particularly as calcium channel blockers. This specific compound features a 4-nitro-benzylidene group attached to the 4-position of the dihydropyridine ring, and a propyl group at the 1-position. The nitro group (-NO2) on the benzylidene moiety introduces an electron-withdrawing effect, which can influence the compound's reactivity and properties. The compound is of interest in medicinal chemistry for its potential cardiovascular effects, although further research is needed to fully understand its therapeutic potential and safety profile.

2605-00-7

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2605-00-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2605-00-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,0 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2605-00:
(6*2)+(5*6)+(4*0)+(3*5)+(2*0)+(1*0)=57
57 % 10 = 7
So 2605-00-7 is a valid CAS Registry Number.

2605-00-7Upstream product

2605-00-7Downstream Products

2605-00-7Relevant academic research and scientific papers

Steric effect in alkylation reactions by N-alkyl-N-nitrosoureas: A kinetic approach

Manso,Perez-Prior,Garcia-Santos,Calle,Casado

body text, p. 932 - 938 (2009/10/26)

The alkylation reactions of 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to DNA base by five N-alkyl-N-nitrosoureas (methyl-, ethyl-, propyl-, butyl-, and allylnitrosourea) were investigated in 7.3 (v/v) water/dioxane medium in the 5.0-6.5 pH range. Decomposition of alkylnitrosoureas (ANU) gives rise to alkyldiazonium ions that yield NBP-R adducts directly or through carbocations in certain instances. The NBP alkylation rate constants by these species were determined. The following sequence of alkylating potential was found: methyl- > ethyl- > allyl- > propyl- > butyl group. Application of Ingold-Taft correlation analysis to the kinetic results revealed that the NBP alkylation reactions occur mainly through steric control. The values of the molar absorption coefficients of the NBP-R adducts also reveal the determinant influence of a steric effect in the formation of alkylation adducts. The kinetic results are consistent with the biological activity of ANU. Copyright

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