260561-85-1

Basic information

• Product Name: Benzoic acid, 4-broMo-2-(broMoMethyl)-, ethyl ester
• Synonyms: Benzoic acid, 4-broMo-2-(broMoMethyl)-, ethyl ester;ethyl 4-bromo-2-(bromomethyl)benzoate
• CAS NO: 260561-85-1
• Molecular Formula: C₁₀H₁₀Br₂O₂
• Molecular Weight: 321.9932
• Mol File: 260561-85-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 375.5±32.0 °C(Predicted)
• Appearance: /
• Density: 1.699±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 4-broMo-2-(broMoMethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-broMo-2-(broMoMethyl)-, ethyl ester(260561-85-1)
• EPA Substance Registry System: Benzoic acid, 4-broMo-2-(broMoMethyl)-, ethyl ester(260561-85-1)

Safety Data

• Hazardous Substances Data: 260561-85-1(Hazardous Substances Data)

Upstream product

• 220389-34-4 ethyl 4-bromo-2-methylbenzoate 

Downstream Products

• 1455091-61-8 4-bromo-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester 
• 1455091-68-5 1-bromo-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester 
• 1455091-65-2 7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester 
• 1455091-64-1 4-(2,6-difluorophenoxy)-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester 
• 1455089-04-9 5-{[7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}pentanoic acid 
• 1455087-53-2 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455092-29-1 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455092-27-9 7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester 
• 1455092-24-6 7-(2-chloro-5-fluorophenoxy)-4-hydroxy-1-iodoisoquinoline-3-carboxylic acid ethyl ester 
• 1455092-23-5 7-(2-chloro-5-fluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester 
• 1455092-20-2 4-(2-chloro-5-fluorophenoxy)-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester 
• 1455087-43-0 1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid 
• 1455091-96-9 1-({[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}methyl)cyclobutanecarboxylic acid tert-butyl ester 
• 1455091-81-2 2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}-4-(pyridin-3-yloxy)benzoic acid ethyl ester 

Relevant articles and documents

Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold

Inhibiting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway is an attractive strategy for tumor immunotherapy. Here, a novel series of indoline-containing compounds were developed, among which, A13 was identified as the most promising PD-1/PD-L1 pathway inhibitor. At the biochemical level, A13 demonstrated strong inhibition of the PD-1/PD-L1 interaction, with an IC50 of 132.8 nM. Notably, it exhibited outstanding immunoregulatory activity, and significantly elevated interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. Therefore, A13 could be employed as a suitable lead compound for further design of non-peptide inhibitors targeting the PD-1/PD-L1 interaction. In addition, the preliminary structure-activity relationships of these new indoline compounds were investigated in this study, providing valuable information for future drug development.