26059-38-1

Upstream product

• 344412-67-5 1-nitro-2-(pent-1-yn-1-yl)benzene 
• 627-19-0 1-Pentyne 
• 615-43-0 2-iodophenylamine 
• 19093-51-7 1-pentynyl copper 
• 764-33-0 hex-2-ynoic acid 
• 609-73-4 o-nitroiodobenzene 
• 693-02-7 hex-1-yne 

Downstream Products

• 13228-41-6 2-propyl-indole 
• 219700-38-6 Methyl (3S)-3-{N-benzyl-N-[(S)-1-phenylethyl]amino}-6-benzyloxyhexanoate 
• 219700-40-0 (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester 
• 219700-39-7 (2R,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester 
• 219700-41-1 (3R,4R,5S)-3-Hydroxy-3-methyl-4-methoxycarbonyl-5-(3'-hydroxypropyl)pyrrolidin-2-one 
• 287477-12-7 (E)-3-(but-1-en-1-yl)-2-phenyl-1H-indole 
• 474335-73-4 (E)-N-benzylidene-2-(1-pentynyl)aniline 
• 1267460-73-0 (Z)-4-butylidene-2-phenyl-4H-3,1-benzoxazine 
• 1267460-74-1 (Z)-4-butylidene-2-(4-methoxyphenyl)-4H-3,1-benzoxazine 
• 1267460-39-8 2,2-dimethyl-N-[2-(pent-1-ynyl)phenyl]propanamide 
• 1267460-40-1 N-[2-(pent-1-ynyl)phenyl]benzamide 
• 1267460-42-3 4-methoxy-N-[2-(pent-1-ynyl)phenyl]benzamide 
• 90585-00-5 N-[2-(pent-1-ynyl)phenyl]ethanamide 
• 1374309-50-8 C₂₂H₂₃NO₂ 

Relevant academic research and scientific papers

Asymmetric Synthesis of 3-Methyleneindolines via Rhodium(I)-Catalyzed Alkynylative Cyclization of N-(o-Alkynylaryl)imines

The first asymmetric synthesis of 3-methyleneindolines from alkynyl imines has been developed via a rhodium-catalyzed tandem process: regioselective alkynylation of the internal alkynes and subsequent intramolecular addition to the imines. The reaction pr

Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/Aza-Michael Addition/Annulation Cascade

We describe here a Cu-catalyzed and 4-OH-TEMPO-mediated sequential dehydrogenation/aza-Michael addition/annulation cascade reaction for the construction of N-alkyl 2-arylindoles from facilely available saturated ketones and 2-arylethynylanilines. This rea

A Synthetic Route to Chiral Benzo-Fused N-Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes

An efficient sequential intramolecular hydroamination/asymmetric hydrogenation reaction under catalysis of a single chiral ruthenium complex or a binary system consisting of achiral gold complex and chiral ruthenium complex has been reported. A diverse range of enantioenriched benzo-fused N-heterocycles, including 1,2,3,4-tetrahydroquinoline, indoline, and 2,3,4,5-tetrahydro-1H-benzo[b]azepine derivatives, were obtained from anilino-alkynes in high yields (up to 98%) with moderate to excellent enantioselectivities (up to 98% ee) under mild conditions. This protocol features good functional group tolerance and high atom economy. Furthermore, this catalytic protocol is applicable to gram-scale synthesis of a naturally occurring alkaloid, (-)-Angustureine.

Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers

An asymmetric cobalt-catalyzed hydroboration/cyclization of 1,7-enynes to synthesize chiral six-membered N-heterocyclic compounds was developed. A variety of aniline-tethered 1,7-enynes react with pinacolborane to afford the corresponding chiral boryl-fun

An efficient synthesis of indoles via a CuMgAl-LDH-catalyzed cyclization of 2-alkynylsulfonanilides

A highly efficient method for the synthesis of indoles has been successfully developed via a CuMgAl-LDH-catalyzed intramolecular annulation reaction of 2-alkynylsulfonanilides. This CuMgAl-LDH catalyst features facile preparation, recovery, and reuse at l

Visible-Light Induced and Oxygen-Promoted Oxidative Cyclization of Aromatic Enamines for the Synthesis of Quinolines Derivatives

The dual transition metal-visible light photoredox catalysis for the synthesis of quinoline derivatives by using dioxygen as an oxygen source is developed. By using visible light, the direct oxidative cyclization of aromatic enamines with alkynes or alkenes can be achieved at mild conditions with an aid of copper or palladium catalysts, and a variety of multisubstituted quinoline derivatives could be obtained in good to moderate yields under mild reaction conditions.

Palladium-Catalyzed Construction of Tetracyclic Scaffolds via the 1,7-Enyne Carbocyclization/Iodophenol Dearomatization Cascade

An efficient palladium-catalyzed dearomatizing [2+2+1] carbocyclization of 1,7-enynes with iodophenols has been developed. A type of tetracyclic scaffold was built in this reaction, exhibiting a broad substrate scope with moderate to excellent yields. More importantly, this method provides a potential strategy for the synthesis of tetracyclic skeleton natural products.

Palladium and copper catalyzed Sonogashira decarboxylative coupling of aryl iodides and alkynyl carboxylic acids

A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reaction of aryl halides and alkynyl carboxylic acids has been developed. Low molecular weight acids, to introduce small building blocks, were specifically used. This method

NOVEL INDOLE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a novel indole derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compound according to the present invention can selectively inhibit histone deacetylase (HDAC), and thus can be used to effectively treat a disease associated with histone deacetylase (HDAC) activity.

Cycloisomerization of 2-alkynylanilines to indoles catalyzed by carbon-supported gold nanoparticles and subsequent homocoupling to 3,3′-biindoles

Elevated by the support: 2-Alkynyl aniline cycloisomerization to indole is catalyzed by cationic Au NPs on a carbon support. Electroneutral and rich 2-aryl indoles are further converted into 3,3′-biindoles by oxidative homocoupling that is readily catalyzed by the Au NPs on carbon, and exclusively but also somewhat sluggishly by the carbon support. Copyright