26065-16-7Relevant academic research and scientific papers
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase
Peduto, Antonella,Bruno, Ferdinando,Dehm, Friedrike,Krauth, Verena,De Caprariis, Paolo,Weinigel, Christina,Barz, Dagmar,Massa, Antonio,De Rosa, Mario,Werz, Oliver,Filosa, Rosanna
, p. 492 - 498 (2014/06/10)
5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and allergic diseases. Here, we present the design, synthesis and
5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof
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, (2008/12/08)
The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y ar
