26066-16-0 Usage
Uses
Used in Pharmaceutical Industry:
Benzene, 1-(chloromethyl)-3-(1-methylethoxy)is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drugs with specific therapeutic properties, contributing to the development of novel treatments for a variety of medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Benzene, 1-(chloromethyl)-3-(1-methylethoxy)is employed as an intermediate for the production of agrochemicals. Its role in the synthesis of these compounds helps in the development of effective pesticides, herbicides, and other agricultural products that are crucial for maintaining crop health and productivity.
Safety Precautions:
Due to the potential hazards associated with Benzene, 1-(chloromethyl)-3-(1-methylethoxy)-, it is essential to handle Benzene, 1-(chloromethyl)-3-(1-methylethoxy)- with proper safety measures. This includes adhering to established chemical handling guidelines and using appropriate personal protective equipment to minimize risks during its use in research and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 26066-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,0,6 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 26066-16:
(7*2)+(6*6)+(5*0)+(4*6)+(3*6)+(2*1)+(1*6)=100
100 % 10 = 0
So 26066-16-0 is a valid CAS Registry Number.
26066-16-0Relevant academic research and scientific papers
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
Egbertson, Melissa,McGaughey, Georgia B.,Pitzenberger, Steven M.,Stauffer, Shaun R.,Coburn, Craig A.,Stachel, Shawn J.,Yang, Wenjin,Barrow, James C.,Neilson, Lou Anne,McWherter, Melody,Perlow, Debra,Fahr, Bruce,Munshi, Sanjeev,Allison, Timothy J.,Holloway, Katharine,Selnick, Harold G.,Yang, Zhiqiang,Swestock, John,Simon, Adam J.,Sankaranarayanan, Sethu,Colussi, Dennis,Tugusheva, Katherine,Lai, Ming-Tain,Pietrak, Beth,Haugabook, Shari,Jin, Lixia,Chen,Holahan, Marie,Stranieri-Michener, Maria,Cook, Jacquelynn J.,Vacca, Joseph,Graham, Samuel L.
supporting information, p. 4812 - 4819 (2015/10/28)
The IC50 of a beta-secretase (BACE-1) lead compound was improved ～200-fold from 11 μM to 55 nM through the addition of a single methyl group. Computational chemistry, small molecule NMR, and protein crystallography capabilities were used to com
SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 37; 43, (2010/11/25)
The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as
