26073-09-6Relevant articles and documents
Dinaphthoporphycenes
Roznyatovskiy, Vladimir,Lynch, Vincent,Sessler, Jonathan L.
, p. 4424 - 4427 (2010)
Figure Presented. Naphthobipyrrole is a potentially useful building block for porphyrin and porphyrin analogue synthesis. Reported here is a simple, generalizable synthetic route to α-formylated, β-substituted naphthobipyrroles and their use in the preparation of binaphthoporphycenes. The resulting binaphthoporphycenes possess a planar geometry as determined via a single-crystal X-ray diffraction analysis; they also display absorption maxima that are bathochromically shifted compared to simple porphycenes.
Design, synthesis and antimalarial evaluation of novel thiazole derivatives
Bueno, José María,Carda, Miguel,Crespo, Benigno,Cu?at, Ana Carmen,de Cozar, Cristina,León, María Luisa,Marco, J. Alberto,Roda, Nuria,Sanz-Cervera, Juan F.
supporting information, p. 3938 - 3944 (2016/08/01)
As part of our medicinal chemistry program's ongoing search for compounds with antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study analyzing their in vitro activities against the chloroquine-sensitive Plasmodium falciparum 3D7 strain. The results indicate that modifications of the N-aryl amide group linked to the thiazole ring are the most significant in terms of in vitro antimalarial activity, leading to compounds with high antimalarial potency and low cytotoxicity in HepG2 cell lines. Furthermore, the observed SAR implies that non-bulky, electron-withdrawing groups are preferred at ortho position on the phenyl ring, whereas small atoms such as H or F are preferred at para position. Finally, replacement of the phenyl ring by a pyridine affords a compound with similar potency, but with potentially better physicochemical properties which could constitute a new line of research for further studies.
3-substituted indole antiproliferative angiogenesis inhibitors
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, (2008/06/13)
3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.
