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Boc-ThionoPro-1-(6-nitro)benzotriazolide is a chemical compound utilized in peptide synthesis, characterized by its role as a coupling reagent. It is a derivative of 6-nitrobenzotriazole, with the Boc (tert-butoxycarbonyl) group providing a protective function for the amine group during the synthesis process. The thiono group in the compound significantly boosts the efficiency of peptide bond formation, and it can be selectively deprotected under mild conditions. Boc-ThionoPro-1-(6-nitro)benzotriazolide is widely used in solid-phase peptide synthesis, facilitating the coupling of amino acids to form peptide chains with high purity and yield, making it an indispensable tool in the production of peptides for research and pharmaceutical applications.

260782-41-0

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260782-41-0 Usage

Uses

Used in Pharmaceutical Industry:
Boc-ThionoPro-1-(6-nitro)benzotriazolide is used as a coupling reagent for the synthesis of peptides, facilitating the formation of peptide bonds with high efficiency and purity. Its protective Boc group ensures the selective deprotection of the amine functionality, which is crucial for the successful synthesis of complex peptide structures.
Used in Research Applications:
In research settings, Boc-ThionoPro-1-(6-nitro)benzotriazolide is employed as a key component in the development of novel peptide-based therapeutics and diagnostic agents. Its ability to enhance peptide bond formation and protect amine groups makes it a valuable asset in the exploration of new peptide sequences and their potential applications in medicine and biology.
Used in Solid-Phase Peptide Synthesis:
Boc-ThionoPro-1-(6-nitro)benzotriazolide is used as a critical reagent in solid-phase peptide synthesis, where it aids in the stepwise assembly of peptide chains on an insoluble support. Its contribution to the process ensures high yields and purity of the final peptide product, streamlining the production of peptides for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 260782-41-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,7,8 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 260782-41:
(8*2)+(7*6)+(6*0)+(5*7)+(4*8)+(3*2)+(2*4)+(1*1)=140
140 % 10 = 0
So 260782-41-0 is a valid CAS Registry Number.

260782-41-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (2R)-2-(6-nitrobenzotriazole-1-carbothioyl)pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:260782-41-0 SDS

260782-41-0Relevant academic research and scientific papers

Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer

Bach, Thorsten,Grab, Hanusch A.,Kirsch, Volker C.,Sieber, Stephan A.

supporting information, p. 12357 - 12361 (2020/05/05)

The first total synthesis of vioprolide D was accomplished in an overall yield of 2.0 % starting from methyl (2S)-3-benzyloxy-2-hydroxypropanoate (16 steps in the longest linear sequence). The cyclic depsipeptide was assembled from two building blocks of

Total synthesis of the cytotoxic cyclopeptide mollamide, isolated from the sea squirt Didemnum molle

McKeever, Benedict,Pattenden, Gerald

, p. 2701 - 2712 (2007/10/03)

Full details of a total synthesis of the novel reverse prenyl substituted cyclic peptide mollamide, isolated from the ascidian Didemnum molle, are described.

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