260783-38-8Relevant articles and documents
(R)- and (S)-N-(Benzyloxycarbonyl)-3,4-epoxybutylamine. New 4-amino-2- hydroxybutyl synthons for the synthesis of hypusine reagents and (R)-6- and (S)-7-hydroxyspermidine
Bergeron, Raymond J.,Bussenius, Joerg,Mueller, Ralf,McCosar, Bruce H.,McManis, James S.
, p. 4285 - 4294 (2007/10/03)
The synthesis and application of the chiral reagents (R)- and (S)-N- (benzyloxycarbonyl)-3,4-epoxybutylamine is described for the first time. These 4-amino-2-hydroxybutyl synthons are successfully employed in the assembly of two hydroxylated triamines, (R)-6- and (S)-7-hydroxyspermidine, and a previously described hypusine reagent, (2S,9R)-11- [(benzyloxycarbonyl)amino]-7-(benzyloxycarbonyl)-2-[(9- fluorenylmethoxycarbonyl)amino]-9-(tetrahydropyran-2-yloxy)-7-azaundecanoic acid, useful for solution- and solid-phase peptide synthesis. (C) 1999 Elsevier Science Ltd.