260784-09-6

Basic information

• Product Name: {2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid
• Synonyms: {2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid
• CAS NO: 260784-09-6
• Molecular Formula: C12H9NO4S2
• Molecular Weight: 295.33416
• Mol File: 260784-09-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: {2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid(260784-09-6)
• EPA Substance Registry System: {2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid(260784-09-6)

Safety Data

• Hazardous Substances Data: 260784-09-6(Hazardous Substances Data)

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 6280-80-4 2-Formylphenoxyacetic acid 

Relevant articles and documents

Synthesis and aldose reductase inhibitory activity of a new series of 5- [[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives

A new series of 5-[[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2- thioxothiazolidine derivatives was synthesized and evaluated for their potency as aldose reductase inhibitors (ARIs). Their activities were examined in terms of their inhibitory effect on rat lens aldose reductase in vitro and in terms of the preventive effect on sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats in vivo. Of these compounds, some of the naphthylmethylene thiazolidine derivatives were comparable to Zenarestat in the inhibitory potency in vitro and in vivo. In particular, compound 30 was 1.5 times more potent than Zenarestat in the in vivo activity, and had an adequate potency for clinical development.