26087-02-5Relevant academic research and scientific papers
Access to Imidazole Derivatives by Silver(I) Carbonate Mediated Coupling of Vinyl Azides with Secondary Amines
Adiyala, Praveen Reddy,Borra, Satheesh,Kamal, Ahmed,Maurya, Ram Awatar
, p. 1269 - 1273 (2016)
An efficient protocol for the synthesis of structurally diverse imidazoles by Ag2CO3-mediated coupling of vinyl azides with secondary amines was developed, and 22 different examples were synthesized in good to high yields. This operationally simple synthetic strategy allows the formation of three new C-N bonds by cascade reactions that involve sp3 C-H functionalization.
Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives: Via a microreactor containing immobilized ruthenium
Adiyala, Praveen Reddy,Jang, Seungwook,Vishwakarma, Niraj K.,Hwang, Yoon-Ho,Kim, Dong-Pyo
supporting information, p. 1565 - 1571 (2020/03/26)
Visible-light-driven continuous-flow decarboxylative annulation was achieved and used along with a microreactor containing immobilized ruthenium catalyst to construct valuable fused imidazole derivatives with high yields under an open atmosphere. Notably, this chemistry included the use of l-proline and α-azidochalcone as precursors of an α-amino radical and 2H-azirine via photo-induced decarboxylation and denitrogenation, respectively, to give the annulated imidazole derivatives as a result of the formation of two new C-N bonds. Moreover the novel, environmentally benign and efficient continuous-flow protocol was further improved by carrying out the reaction in a polydimethylsiloxane (PDMS) microreactor with immobilized Ru3+ under fluorescent or white LED light, enabling excellent yields (70-94%) at a reaction time (2 min) significantly shorter than that (16 h) of the batch protocol.
Access to Imidazo[1,2-a]pyridines via Annulation of α-Keto Vinyl Azides and 2-Aminopyridines
Adiyala, Praveen Reddy,Mani, Geeta Sai,Nanubolu, Jagadeesh Babu,Shekar, Kunta Chandra,Maurya, Ram Awatar
supporting information, p. 4308 - 4311 (2015/09/15)
A novel strategy for the synthesis of imidazo[1,2-a]pyridines via efficient catalyst/metal-free annulations of α-keto vinyl azides and 2-aminopyridines is described. Several imidazo[1,2-a]pyridines were synthesized from readily available vinyl azides and
