26087-98-9

Usage

Uses

Used in Pharmaceutical Industry:
BIS (4-METHYL-1-HOMO-PIPERAZINYLTHIOCARBONYL) DISULFIDE is used as a dopamine β-hydroxylase inhibitor for its ability to regulate the conversion of dopamine to norepinephrine, which can be beneficial in the treatment of certain neurological disorders.
Used in Neurological Research:
As a noradrenergic agent, BIS (4-METHYL-1-HOMO-PIPERAZINYLTHIOCARBONYL) DISULFIDE is used to study the effects of norepinephrine on the central nervous system. Its ability to shorten the latency of seizures induced by chloroquine makes it a valuable tool in understanding the underlying mechanisms of seizure activity and potential treatments.
Used in Chemical Synthesis:
Due to its unique chemical structure, BIS (4-METHYL-1-HOMO-PIPERAZINYLTHIOCARBONYL) DISULFIDE can be utilized as an intermediate in the synthesis of various pharmaceutical compounds and other organic molecules, contributing to the development of new drugs and materials.

InChI:InChI=1/C14H26N4S4/c1-15-5-3-7-17(11-9-15)13(19)21-22-14(20)18-8-4-6-16(2)10-12-18/h3-12H2,1-2H3/p+2

Upstream product

• 4318-37-0 1-Methylhomopiperazine 

Relevant academic research and scientific papers

Homopiperazine derived female controlled vaginal trichomonacidal contraceptive: An addition to structure-activity relationship

Background: In our previous work, several piperazine derived bis(dialkylaminethiocarbonyl) disulfides and disulfide esters of dithiocarbamic acid have been synthesized and evaluated for their spermicidal and microbicidal efficacy. These studies have provided some promising compounds for developing a dually active vaginal microbicidal contraceptive which is under pre-clinical stage. Objective: The main objective of this study was the design synthesis and biological evaluation of bis(dialkylaminethiocarbonyl) disulfides (4–15) and 2,2’-disulfanediylbis (3-(substituted-1-yl) propane-2,1-diyl) disubstituted-1-carbodithioates (19-28) as non-surfactant molecules capable of eliminating Trichomonas vaginalis as well as irreversibly immobilizing 100% human sperm promptly. Method: Spermicidal, anti-trichomonas, cytotoxicity and biocompatibility study of the synthesized compounds was done as per the reported methodologies. Result: Among bis(dialkylaminethiocarbonyl) disulfides (4-15, Table 1), compound 4 (MEC 0.02 mM) was found to be the most desirable for spermicidal activity as it was 40 times more active than Nonoxynol-9 (N-9), and also active against Trichomonas vaginalis (MIC 0.02 &1.10 mM). 2, 2’-disulfanediylbis (3-(substituted-1-yl) propane-2, 1-diyl) disubstituted-1-carbodithioates (19-28, Table 2), and compounds (19, 22, 23, and 24 MEC 0.05 mM) were sixteen times more active than N-9 with promising Trichomonacidal activity. Conclusion: This study suggested that the disulfide linkage alone and dithiocarbamate along with disulfide group within the same chemical entity impart the desired multiple activities of compounds.

Combinations for the treatment of fungal infections

The invention features methods and compositions for treating a patient diagnosed with, or at risk for developing, a fungal infection.