26088-79-9

Usage

Uses

Used in Organic Chemistry:
2-(4-Acetamidobenzylidene)malononitrile is used as a starting material or intermediate for various reactions in the field of organic chemistry. Its high reactivity allows for the synthesis of a wide range of compounds, making it a versatile component in chemical research and development.
Used in Chemical Synthesis:
Due to its reactive nature, 2-(4-Acetamidobenzylidene)malononitrile is employed as a key component in the synthesis of various complex molecules. Its ability to participate in multiple types of chemical reactions, such as condensation and substitution, makes it a valuable asset in the creation of new compounds with potential applications in various industries.
Safety Considerations:
Although 2-(4-Acetamidobenzylidene)malononitrile has not been extensively studied, it is likely to be hazardous, similar to other malononitriles. Therefore, it is essential to handle 2-(4-Acetamidobenzylidene)malononitrile with caution, following proper safety protocols and guidelines to minimize potential risks and ensure the safety of researchers and the environment.

InChI:InChI=1/C12H9N3O/c1-9(16)15-12-4-2-10(3-5-12)6-11(7-13)8-14/h2-6H,1H3,(H,15,16)

Upstream product

• 17082-32-5 2-(4-aminobenzylidene)malononitrile 
• 108-24-7 acetic anhydride 
• 122-85-0 para-acetamidobenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 96462-45-2 (4-acetylamino-phenyl)-ethenetricarbonitrile 
• 1239708-63-4 t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate 
• 1239708-57-6 t-butyl 4-((4-(3-(6-((4-amino-6-(4-aminophenyl)-5-cyanopyrimidin-2-ylthio)methyl)pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate 
• 1239708-56-5 3-(6-(4-Amino-6-(4-aminophenyl)-5-cyanopyrimidin-2-ylthio-methyl)pyridin-2-yl)propionic acid 

Relevant academic research and scientific papers

Pseudo-five-component organocatalyzed synthesis of dicyanoanillines using only malononitrile and aromatic aldehydes

A pseudo-five-component reaction leading to efficient synthesis of dicyanoanillines was developed using only aromatic aldehydes and malononitrile as the starting reactants. Mechanistic studies suggested that a malononitrile dimer and the Knoevenagel conde

Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes

Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor

A new series of amino-3,5-dicyanopyridines (3–28) as analogues of the adenosine hA2B receptor agonist BAY60-6583 (compound 1) was synthesized. All the compounds that interact with the hA2B adenosine receptor display EC50 v

Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging

Central adenosine A1 receptor (A1R) is implicated in pain, sleep, substance use disorders, and neurodegenerative diseases, and is an important target for pharmaceutical development. Radiotracers for A1R positron emission t

Green one-pot synthesis of novel polysubstituted pyrazole derivatives as potential antimicrobial agents

Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly pr

NOVEL CYANOPYRIMIDINE DERIVATIVE

The present invention relates to a novel cyanopyrimidine compound and a pharmaceutical composition which have a safe and potent adenosine A2a receptor agonistic activity.

Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof

This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, p