26088-83-5

Upstream product

• 122-03-2 (4-isopropylbenzaldehyde) 
• 109-77-3 malononitrile 

Downstream Products

• 75076-23-2 (2S,5R)-4-Amino-5-(4-chloro-phenyl)-6-(ethyl-phenyl-amino)-2-(4-isopropyl-phenyl)-2,5-dihydro-pyridine-3-carbonitrile 
• 75076-23-2 (2R,5R)-4-Amino-5-(4-chloro-phenyl)-6-(ethyl-phenyl-amino)-2-(4-isopropyl-phenyl)-2,5-dihydro-pyridine-3-carbonitrile 
• 1239897-26-7 dimethyl 6-amino-5-cyano-4-(4-isopropylphenyl)-1-(p-tolyl)-1,4-dihydropyridine-2,3-dicarboxylate 
• 75076-39-0 4-Amino-5-(4-chloro-phenyl)-6-(ethyl-phenyl-amino)-2-(4-isopropyl-phenyl)-nicotinonitrile 
• 220986-28-7 2?amino?4?(4?isopropylphenyl)?7?methyl?5?oxo?4H,5H?pyrano[4,3?b]pyran?3?carbonitrile 

Relevant academic research and scientific papers

Synthesis of functionalized 1-benzamido-1,4-dihydropyridines via a one-pot two-step four-component reaction

The one-pot four-component reaction of benzohydrazide, acetylenedicarboxylate, aromatic aldehydes and malononitrile in ethanol with triethylamine as base catalyst afforded functionalized 1-benzamido-1,4-dihydropyridines in satisfactory yields. Under simil

Molecular size- and shape-selective Knoevenagel condensation over microporous Cu3(BTC)2 immobilized amino-functionalized basic ionic liquid catalyst

A novel molecular size- and shape-selective catalyst, microporous metal-organic framework HKUST-1 immobilized amino-functionalized basic ionic liquid (ABIL-OH), was synthesized by facile impregnation and activation. Characterizations and catalytic results

Tin oxide nanoparticles (NP-SnO2): Preparation, characterization and their catalytic application in the Knoevenagel condensation

Tin oxide (SnO2) nanoparticles were synthesized by modified thermal decomposition process. Taguchi analysis was used and three important synthetic factors, molar concentration ratio of [NaNO3]/[SnCl 4], temperature and tim

A novel four-component synthesis of ethyl 6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates

Ethyl 6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates were synthesized via a four-component reaction of the sodium salt of diethyloxaloacetate, an aromatic aldehyde, hydrazine hydrate, and malononitrile. The products were obtained i

Knoevenagel reaction catalyzed by a reusable Br?nsted acid based on 1-alkyl-1, 2, 4-triazolium tetrafluoroborate

The Knoevenagel reaction is one of the most useful methods for the synthesis of α, β- unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes with malononitrile catalyzed by 1-alkyl-1, 2, 4-triazolium salts to aff

An efficient Knoevenagel condensation of aldehydes with active methylene compounds over novel, robust CeZrO4?δ catalyst

Abstract: In the present work, we explored novel CeZrO4?δ as a catalyst for Knoevenagel condensation of aldehydes with reactive methylene compounds like malononitrile and ethylcyanoacetate. For the present study, ceria, zirconia and CeZrO4

Five porous zinc(II) coordination polymers functionalized with amide groups: Cooperative and size-selective catalysis

Five functionalized porous coordination polymers 1-5 with highly ordered amide groups in the channels show notable interaction with guest molecules. The amide groups functioned as trigger sites and catalytically driven forces to activate substrate proximi

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes,

Synthesis of polysubstituted dihydropyridines by four-component reactions of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate

A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.