26088-96-0

Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 
• 109-77-3 malononitrile 

Downstream Products

• 120131-37-5 2-[(E)-3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-(4-nitro-phenyl)-allylidene]-malononitrile 
• 106000-63-9 5′-amino-3′-methyl-4,4″-dinitro-[1,1′:3′,1′-terphenyl]-4′,4′,6′(3′H)-tricarbonitrile 
• 131534-30-0 2-amino-4-methyl-4-(p-nitrophenyl)-6-phenyl-4H-pyran-3,5-dicarbonitrile 
• 100-19-6 (4-nitrophenyl)ethanone 

Relevant academic research and scientific papers

Synthesis and evaluation of 4-anilinoquinazoline bioisosteres as potential anti-breast cancer agents

Based on one of the four major categories of scaffold hopping theory namely hetrocycle replacements, a series of 5-arylthieno[2,3-d]pyrimidines had been prepared and evaluated as anti-breast cancer agents. Optimization by combination of different pharmacophores with the thienopyrimidine scaffold led to discovery of biologically active compounds.

A Zn based metal organic framework as a heterogeneous catalyst for C-C bond formation reactions

Herein, we report the synthesis and application of a Zn-Bp-BTC MOF (Bp-4,4′-bipyridine; BTC-1,3,5-benzene tricarboxylic acid; MOF-metal organic framework) as a heterogeneous catalyst for mediating organic reactions. Initially, conditions were optimized for the Knoevenagel condensation reaction using Zn-Bp-BTC as a heterogeneous catalyst by varying the solvent, temperature and catalyst loading. Although the reaction proceeded at room temperature using methanol as the solvent, 60 °C offered the best yield in a shorter duration. Under optimized reaction conditions, a wide range of α,β-unsaturated dicyano compounds were prepared from the corresponding carbonyl precursor and malononitrile, the active methylene counterpart. Systematic investigation was also carried out to assess the role of the ligand and metal salt in the Knoevenagel condensation reaction. It was found that the Zn-Bp-BTC MOF catalyzed the reaction efficiently in comparison to its analogue Zn-BTC MOF and precursor Zn(NO3)2·6H2O. Finally, catalytic recycling and stability studies showed that the catalyst is able to mediate the reaction for up to five consecutive cycles without undergoing any significant chemical or morphological changes. Further, the catalyst was tested for its efficacy in a multi-component reaction (MCR). A MCR with the Zn-Bp-BTC MOF as the catalyst afforded good yields and there was no reaction in the absence of the catalyst. Similarly, the catalyst was tested for its efficiency in benzimidazole synthesis.

Syntheses of donor-acceptor-functionalized dihydroazulenes

The dihydroazulene (DHA)/vinylheptafulvene (VHF) photo/thermoswitch has been of interest for use in molecular electronics and advanced materials. The switching between the two isomers has previously been found to depend strongly on the presence of donor a

A Simple and Clean Synthesis of Polysubstituted 2,6-Dicyanoanilines Catalyzed by KF/alumina

A simple and clean synthesis of polysubstituted 2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenemalonodinitriles in ethanol catalyzed by KF/ alumina. Use of non-hazardous solid base as a catalyst,

SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME

The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts t

Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N'-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate

A crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-[2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.

Crystalline N-(4-(4-ammoniumthieno[2,3-d]pyrimidin-5-yl)phenyl)-N'-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanesulfonate

A crystalline N-(4-(4-ammoniumthieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanesulfonate, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.

New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multitargeted kinase inhibitor

Novel conditions have been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald reaction. The benefits of these conditions are their mildness, and the ease of product isolation. Thus,

A practical and selective reduction of nitroarenes using elemental sulfur and mild base

A method was developed to reduce aromatic nitro compounds to the corresponding anilines using sulfur and base. The method tolerates a range of functional groups on the benzene ring, avoids the use of hydrogen and transition metals and provides the anilines in moderate to high yields.

Novel kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.