26089-54-3

Usage

Properties

1. Name: 2-acetyl-3,5-dihydroxyphenyl beta-D-glucopyranoside
2. Common name: Arbutin
3. Type: Glycoside compound
4. Source: Naturally found in plants such as bearberry, blueberry, and cranberry
5. Skin benefits: Skin-lightening, brightening, and antioxidant properties

Specific content

1. Skin-lightening and brightening properties due to its ability to inhibit melanin production
2. Works by decreasing the activity of tyrosinase enzyme responsible for melanin production
3. Improves appearance of hyperpigmentation, age spots, and skin discoloration
4. Antioxidant properties protect skin from free radical damage
5. Promotes a more youthful and radiant complexion

Upstream product

• 133-89-1 UDP-glucose 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 911459-40-0 (2-acetyl-5-benzoyloxy-3-hydroxy-phenyl)-(tetra-O-acetyl-β-D-glucopyranoside) 

Relevant academic research and scientific papers

Exploring the aglycon promiscuity of a new glycosyltransferase from Pueraria lobata

Enzymatic glycosylation catalyzed by glycosyltransferases has great potential for creating bioactive glycosylated small-molecule compounds. Here, we highlight the aglycon promiscuity of a new glycosyltransferase (PlGT7) from Pueraria lobata. PlGT7 exhibited the capability to glycosylate 26 structurally diverse drug-like scaffolds and simple phenolics with UDP-glucose to form O-, S-, and N-glycosides. The reversibility of PlGT7 coupled with its substrate flexibility was also exploited to generate bioactive glucosides with simple sugar donor. These studies indicate the significant potential of an enzymatic approach to the glycosylation of bioactive natural and unnatural products in drug discovery.

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotective and neuroprotective agents. Although quite a few potent inhibitors of the equilibrative nucleoside transporters are known, largely missing are the concentrative nucleoside transporter inhibitors. Phloridzin (3, Ki = 16.00 μM) is a known moderate inhibitor of the concentrative nucleoside transporters. We have synthesized and evaluated analogs of phloridzin at the hCNT3 nucleoside transporter. Within the series of synthesized analogs compound 16 (Ki = 2.88 μM), possessing a ribofuranose sugar unit instead of a glucopyranose as present in phloridzin, exhibited the highest binding affinity at the hCNT3 transporter. Phloridzin and compound 16 have also been shown to be selective for the hCNT3 transporter as compared with the hENT1 transporter. Compound 16 can serve as a new lead which after further modifications could yield selective and potent hCNT3 inhibitors.