260975-13-1Relevant academic research and scientific papers
Synthesis of covalent [14C]-labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL-1
Eggler,Gabel,Zandi,Weaver,McKechney,Dombroski,Peurano,Hawryluk
, p. 785 - 794 (2007/10/03)
CP-452,759 and CP-470,947, two covalent [14C]-labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL-1 from human monocytes, have been synthesized. The radiosyntheses utilize [14C]-labeled phosgene to prepar
DIARYLSULFONYLUREA BINDING PROTEINS
-
, (2008/06/13)
The present invention relates to the identification of diarylsulfonylurea binding proteins (DBPs) as therapeutic targets for agents that suppress the release of inflammatory mediators such as interleukin IL-1 and IL-1β.
