26108-83-8Relevant academic research and scientific papers
METABOLISM OF 17α-METHYLTESTOSTERONE IN THE RABBIT: C-6 and C-16 HYDROXYLATED METABOLITES
Templeton, John F.,Jackson, Chung-Ja Choi
, p. 115 - 122 (1983)
17α-Methyltestosterone and the reduced metabolites, 17α-methyl-5α-androstane-3α,17β-diol, 17α-methyl-5α-androstane-3β,17β-diol and 17α-methyl-5β-androstane-3α,17β-diol, together with three hydroxylated metabolites, 17α-methyl-5β-androstane-3α,16α,17β-triol, 17α-methyl-5β-androstane-3α,16β,17β-triol and a new metabolite, 17α-methyl-5α-androstane-3β,6α,17β-triol, were isolated and identified in the urine of rabbits dosed with 17α-methyltestosterone.No hydroxylated 5α-metabolite of 17α-methyltestosterone has been identified previously.No evidence for epimerization at the C-17 position was observed.
Metabolism of 17α-methyl-5β-dihydrotestosterone in the rabbit
Templeton,Choi Jackson
, p. 493 - 500 (2007/10/02)
17α-Methyl-5β-androstane-3α,17β-diol together with the hydroxylated metabolites 17α-methyl-5β-androstane-1β,3α,17β-triol, 17α-methyl-5β-androstane-3α,12β,17β-triol, 17α-methyl-5β-androstane-3α,16α,17β-triol and 17α-methyl-5β-androstane-3α,16β,17β-triol were isolated and identified in the urine of rabbits orally dosed with 17α-methyl-5β-dihydrotestosterone. Biotransformations differ from the 5α-series where hydroxylation occurred at C-6 and C-15. In both series, the C-3 equatorial epimer was the major urinary excretion product among the non-hydroxylated metabolites. The 5β-compound was more resistant to metabolic hydroxylation than the 5α-compound. No evidence for epimerization at the C-17 position was observed.
